Combination of NHF and Nebulizer on Lung Function in COPD

Effect of Nasal Highflow in Combination With a Nebulizer on Reversibility in Lung Function in Patients With COPD

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02885103

Acronym

AEROFLOW

Enrollment

Registered

2016-08-31

Start date

2016-08-31

Completion date

2017-11-30

Last updated

2018-03-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Obstructive Pulmonary Disease

Keywords

NHF, nasal highflow

Brief summary

This study will prove to concept of effectiveness of NHF in combination with a nebulizer on reversibility of lung function in COPD patients.

Detailed description

Patients will inhale on day 1 with a nebulizer and on another day with combination of nebulizer an NHF in a randomised order.

Interventions

DEVICENasal high flow (NHF)

NHF will be combinated with a nebulizer. Inhalation will be done on nasal cavity.

DEVICENebulizer

Inhalation will be done will Nebulizer and via mouth

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* stable disease * COPD

Exclusion criteria

* exacerbation * right heart decompensation * acute respiratory insufficiency * acute disease

Design outcomes

Primary

Measure	Time frame	Description
changes in forced expiratory volume in 1s (FEV1)	45 minutes	litre
changes in breath way resistance (Rtot)	45 min	—

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 25, 2026