IVF Outcome After Bariatric Surgery

In Vitro Fertilization (IVF) Outcome After Bariatric Surgery: a Multicentric Case-control Study.

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02884258

Enrollment

249

Registered

2016-08-30

Start date

2012-01-31

Completion date

2017-12-31

Last updated

2019-11-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility, Obesity

Keywords

Assisted Reproductive Technology, Obesity, Bariatric Surgery, Infertility, Fertility Preservation

Brief summary

This case-control study compares IVF results and live birth rates in women undergoing IVF with a history of bariatric surgery as compared to 2 age-matched control groups composed of (A) non-operated women matched on cases' post-operative BMI (controls 1) and (B) non-operated severely obese women (controls 2).

Detailed description

A preliminary study in the participating center showed a trend to lower ovarian response to stimulation and live birth rates after bariatric surgery compared to weight-matched patients. However, statistical significance was not reached, as the sample size was small. The aim of the research project is to study the ovarian response and live birth rates of this bariatric surgery population, with a sufficient number of patients, in order to reach higher statistical power. This case-control study will involve 3 IVF (in-vitro fertilization) centers in France . All patients undergoing IVF with a history of bariatric surgery will be included from January 2012. Each case will be matched for BMI and age to the 2 next patients without bariatric surgery history and undergoing IVF and to one non-operated severely obese woman. Surgery procedures include sleeve gastrectomies and by-passes. The IVF results and live birth rates will be compared between the three groups.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

OTHER

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 43 Years

Healthy volunteers

Yes

Inclusion criteria

* Undergoing IVF and with a history of bariatric surgery

Design outcomes

Primary

Measure	Time frame	Description
Live birth rates	nine months after embryo transfer	number of live births divided by the number of embryo transfers

Secondary

Measure	Time frame	Description
average number of mature oocytes obtained	The day of oocyte retrieval in the case of IVF with sperm injection (ICSI) just after decoronisation, or on day one after oocyte retrieval in classical IVF. Oocyte retrieval occurs 36 hours after hCG injection after an ovarian stimulation protocol.	the average number of mature oocytes obtained per IVF cycle

Countries

France

Outcome results