Effects of Weight on Inflammation and Colon Cancer Risk

Study on the Effects of Weight on Inflammation and Colon Cancer Risk

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02884024

Enrollment

Registered

2016-08-30

Start date

2011-01-31

Completion date

2013-02-28

Last updated

2016-08-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colorectal Cancer

Keywords

obesity, inflammation, cancer risk

Brief summary

An observational study designed to compare colonic cytokine concentrations in lean versus obese individuals

Detailed description

An observational study was performed on 43 individuals undergoing routine screening colonoscopy, some of whom were lean and some who were obese. They had weight, height, and waist-hip ratio measured at the time of colonoscopy and had additional colonic biopsies to measure colonic cytokines.

Interventions

OTHERno intervention

there is no intervention in this study

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

40 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

1. Caucasian 2. undergoing clinically-indicated screening colonoscopy 3. BMI\< or = 25, or 30+

Exclusion criteria

1. past history of cancer (except non-melanoma skin cancer) 2. a polyposis syndrome 3. any current or chronic inflammatory disease or infection 4. incapable of providing valid informed consent

Design outcomes

Primary

Measure	Time frame
colonic concentration of Tumor Necrosis Factor-alpha	time zero: at baseline
colonic concentration of Interleukin-6	time zero: at baseline
colonic concentration of Interleukin-1 beta	time zero: at baseline
colonic concentration of Interferon-gamma	time zero: at baseline

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026