Cardiac Myosins, Exercise, Patients
Conditions
Brief summary
This study aimed to determine if eight-weeks of exercise-based cardiac rehabilitation could improve adiponectin and cardiovascular disease risk factors in overweight coronary heart disease patients. Patients were included in the study if: they were approved to do so following a physical, physiological and psychological test; did not take part in regular physical activity; had stable heart failure for at least 3 months. Exclusion criteria included: a history of surgery within the preceding 4 months; had an unstable angina, acute phase of myocardial infarction, and/or unstable arrhythmia; had obstructive cardiomyopathy, exercise-induced ischemia or arrhythmias, uncontrolled arrhythmias, resting blood pressure more than 200/120 millimeters mercury, aortic stenosis, and/or peripheral artery disease; exercise limitations due to neuromuscular and/or musculoskeletal disease; had any health problems that prevented maximum effort on the treadmill test. Target population included of all patients with a history of myocardial infarction and diagnosis of congestive heart failure who were referred to Isfahan Cardiovascular Research Centre. 60overweight coronary heart disease patients were randomly assigned to either an eight-week, three times weekly exercise group (n=30), or a non-exercising control group (n=30). Exercise sessions took place at 60-85% of maximal heart rate, lasted 45-60 minutes and included a 10-minute warm-up, 40 minutes of aerobic exercises, consisting of stationary cycling, walking and/or jogging, flexibility, balance exercises, and weight-bearing activity and a 10-minute cool-down.
Interventions
OTHERExperimental
Doing exercise at 60-85% of maximal heart rate, lasted 45-60 minutes and included a 10-minute warm-up, 40 minutes of aerobic exercises, consisting of stationary cycling, walking and/or jogging
OTHERControl
They did not do ant exercise training during 8 weeks.
Sponsors
University of Isfahan
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* they were approved to do so following a physical, physiological and psychological test; resided and worked in the city of Isfahan; did not take part in regular physical activity; had stable heart failure for at least 3 months.
Exclusion criteria
* a history of surgery within the preceding 4 months * had an unstable angina, acute phase of myocardial infarction (MI), and/or unstable arrhythmia * had obstructive cardiomyopathy, exercise-induced ischemia or arrhythmias, uncontrolled arrhythmias, resting blood pressure more than 200/120 millimeters mercury (mmHg), aortic stenosis, and/or peripheral artery disease * exercise limitations due to neuromuscular and/or musculoskeletal disease, such as any type of orthopedic, low back pain, bone fracture of less than 6 months * uncontrolled systemic disease, such as DM; were 75 years or older * had any health problems that prevented maximum effort on the treadmill test * unable to answer the screening questionnaires assessing depression and anxiety.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Effect of Exercise-based cardiac rehabilitation on Serum levels of adiponectin was measured by ELISA method | up to 8 weeks | Exercise sessions took place at 60-85% of maximal heart rate, lasted 45-60 minutes. |
| Effect of Exercise-based cardiac rehabilitation on lipids was measured by ELISA method | up to 8 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| Effect of Exercise-based cardiac rehabilitation on weight was measured | up to 8 weks |
| Effect of Exercise-based cardiac rehabilitation on height was measured | up to 8 weks |
Outcome results
None listed