Cerebral Artery Occlusion
Conditions
Brief summary
The Ischemic Brain Vascular Accident (CVA) is a major public health issue. An Early and appropriate charging anyone with stroke is essential to reduce mortality, reduce dependency and promote recovery of autonomy. Intravenous fibrinolysis in patients with cerebral infarction (NINDS 1995), is reserved for a small proportion of highly selected patients. It therefore remains a significant therapeutic challenge, especially for patients with against-indications to fibrinolysis or in whom there is no immediate benefit. For twenty years of mechanical devices have been developed to remove, as quickly as possible, the cause of intracranial arterial occlusion and allow restoration of blood flow before brain damage is irreversible. NTF The protocol is part of the evaluation process of our clinical practices recommended by the National Health Authority (HAS), in the specific context of mechanical thrombectomy performed in French centers of interventional neuroradiology working with neurovascular units (A V).
Interventions
None listed
Sponsors
Nantes University Hospital
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Signature of the information notice by the patient or his legal representative * Age\> 18 years * Clinical and imaging consistent with ischemic stroke whose symptoms start back within 8h * Thrombosis (TICI 0 or 1) of the carotid T, M1, M1-M2 bifurcation of the basilar artery occlusion in TANDEM ACI / M1.
Exclusion criteria
* Pregnant or lactating women * Rapid improvement of NIHSS (gain of more than 4 points) between two pre-treatment assessments. * ASPECT score \<7 on the scanner or \<5 on the diffusion-weighted imaging (DWI) * Intracranial hemorrhage on imaging * Inability of clinical evaluations at 3 months * extensive lesions of the brain stem (the presence of a complete section of the brainstem hyperintense b1000) * 0 Refusal to participate in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| clinical score for handicap (mRS) | at 3 months |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| hemorrhagic complications on postoperative imaging | baseline | — |
| physiological parameter : age | baseline | Factors of good clinical prognosis |
| presence of coronary artery disease | baseline | Factors of good clinical prognosis |
| presence of arterial hypertension | baseline | Factors of good clinical prognosis |
| presence of diabetes | baseline | Factors of good clinical prognosis |
| presence of hypercholesterolemia | baseline | Factors of good clinical prognosis |
| presence of intracranial stenosis | baseline | Factors of good clinical prognosis |
| presence of occlusive arterial disease | baseline | Factors of good clinical prognosis |
| presence of haematological disorders | baseline | Factors of good clinical prognosis |
| presence of neoplasia | baseline | Factors of good clinical prognosis |
| NIHSS score | baseline | Factors of good clinical prognosis |
| ASPECTS score | baseline | Factors of good clinical prognosis |
| MRI imaging of stroke | baseline | Factors of good clinical prognosis |
| unblocking rate based on the score TICI | at 3 months | — |
| NIHSS evaluation | at 24h | — |
| Influence of collaterality score on the NIHSS | at 24h | — |
| Influence ASPECTS score on the NIHSS | at 24h | — |
| influence of anesthesia on the NIHSS | at 24h | — |
| hemorrhagic complications | at 24h | — |
| Influence of hemorrhagic complications on NIHSS | at 24h | — |
Countries
France
Contacts
PRINCIPAL_INVESTIGATORHubert DESAL, PU-PH
Nantes University Hospital
Outcome results
None listed