Intrauterine Growth Restriction, Preeclampsia
Conditions
Keywords
Placental volume, First-trimester screening, Ultrasound, Preeclampsia, Intrauterine growth restriction, Biochemical markers, Uterine artery doppler
Brief summary
Preeclampsia (PE) and intrauterine growth restriction (IUGR) are clinical manifestations of placental insufficiency. These complications affect 5-15% of pregnancies, and are responsible for up to 20% of preterm births. Women who develop PE during pregnancy also have an increased risk for cardiovascular events, both at short and long term. This justifies the need to improve diagnostic tools to identify patients at risk for these complications. PE and IUGR are multifactorial entities. Screening algorithms should thus include several parameters to achieve high detection rates. Research has mainly focused in the analysis of biophysical and biochemical parameters, and the study of the placenta itself has not been included in current diagnostic strategies. Investigators hypothesize that detection rates of preeclampsia and intrauterine growth restriction could be improved by the study of placental characteristics in the first trimester of pregnancy.
Interventions
OTHERUltrasound study of the placenta
The placenta will be scanned to measure the placental volume, chorionic plate, basal plate and thickness.
OTHERMeasurement of angiogenic and anti-angiogenic factors (sFlt-1 and PlGF) in the first trimestre blood test
Sponsors
Spanish Clinical Research Network - SCReN
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
11 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* pregnancies with fetuses with CRL between 45 and 80mm * absence of chromosomal abnormalities * absence of congenital anomalies * absence of congenital infections
Exclusion criteria
* patient not accepting to participate in the study * multiple pregnancies * pregnancies without ultrasonographic confirmation of gestational age
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Development of preeclampsia | Up to birth | Pre-eclampsia is diagnosed after 20 week of gestation with systolic blood pressure equal to or greater than 140 mmHg, diastolic blood pressure equal to or greater than 90 mmHg and proteinuria greater than or equal 0.3 g/d by 24 hour urine collection |
| Development of intrauterine growth restriction | At birth | Intrauterine growth restriction is defined as birthweight below 10th centile according to local standards |
Countries
Spain
Outcome results
None listed