Comorbidities and Indirect Health State Utility in Hip and Knee Osteoarthritis

Impact of Comorbidities on Measure of Indirect Utility Change in Hip and Knee Ostearthritis

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02879890

Acronym

COMUTAR

Enrollment

878

Registered

2016-08-26

Start date

2009-03-31

Completion date

2014-03-31

Last updated

2016-08-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis

Brief summary

National cohort study aimed to investigate the impact of comorbidities (number and type of comorbidities) on health utility state change in lower lim osteoarthritis (hip and knee OA).

Detailed description

The concept of health utility state was developed by economists to explain individual choices and preferences for health states. It is expressed as the desirability or preference that individuals exhibit for the condition. This health utility state can be measured indirectly using health-relation quality of life questionnaires. Chronic diseases such as OA are known to be associated with impairment of quality of life. Given that OA prevalence increases with age, OA is often associated with other diseases (comorbidities). A cross-sectional study showed that comorbidities are associated with lower health utility state in OA. Investigation of longitudinal impact of comorbidities on health utility state change is need. Main objective: Determine the impact of comorbidities on change in health utility state among patients with lower limb OA. Secondary objective: Determine the Minimal Clinically important Difference in health utility state among patients with lower limb OA. The COMUTAR study uses longitudinal data from the Knee and Hip Osteoarthritis Longitudinal Assessment (KHOALA) cohort study. Health utility state is measured indirectly using Medical Outcome Study Short Form-36 quality of life questionnaire Comorbidities are assessed using the Functional Comorbidity Index

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

40 Years to 75 Years

Healthy volunteers

Inclusion criteria

* age: 40-75 years * Uni or bilateral lower limb osteoarthritis (OA) according to the American College of Rheumatology (ACR) and European league against rheumatism (EULAR) criteria

Exclusion criteria

* Hip or knee prothesis * Antecedent of osteotomy * Severe comorbidity * Adult under legal protection

Design outcomes

Primary

Measure	Time frame	Description
Change in health utility state	Five years	Change in health state utility score between the inclusion in the KHOALA cohort and 5 years later (T5-T0)

Secondary

Measure	Time frame
Minimal Clinically Important Difference (MCID) of health utility state	Five years

Outcome results