Work Related Asthma
Conditions
Brief summary
The purpose is to compare clinical, functional, professional and socio-economical characteristics of patients with occupational asthma and work aggravated asthma. Secondary purposes are: * to evaluate diagnostic value of new non-invasive techniques such as exhaled nitric oxide and cytology of induced expectoration; * to estimate medical-social becoming of diagnosed work-related asthma after one year; * to establish a biobank of blood samples of individuals with work related asthma for measurement of cytokines and search for genetic polymorphisms associated with asthma.
Detailed description
Participants with work related asthma or suspected work related asthma will obtain a precise diagnosis concerning severity and control of respiratory disorder and also the possible effect of professional environment on the disorder. Their medical care and medico-legal care, in case of recognition of occupational disease, could be ameliorated. In general, this study will allow the harmonization of diagnostic care and medical, medico-professional and medico-legal management of cases of work related asthma in specialized hospitals.
Interventions
OTHERBlood sample
Biobank. Analysis of cytokines and DNA polymorphisms
Sponsors
Central Hospital, Nancy, France
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
16 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
\- Patient consulting for suspected work-related asthma in one of hospitals participating to the study
Exclusion criteria
* Patient refusing to participate * Pregnant or breastfeeding women * Individual in life-threatening emergency * Hospitalized patient * Patient in a health or social institution * Person deprived of liberty * Person with total occupational disability * Retired person * Person diagnosed as non-asthmatic * Asthmatic person already enrolled in a clinical trial of bio-therapy to treat asthma
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Classification of suspected work-related asthma in occupational asthma, work aggravated asthma, non-work-related asthma | Inclusion | Interpretation of diagnostic algorithm of study |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Cytology of induced expectoration | Inclusion | Bronchial inflammation marker |
| Nonspecific bronchial hyperreactivity evaluated with metacholine bronchial challenge test and/or isocapnic hyperventilation test | Inclusion | — |
| Nitric oxide level | Inclusion | Bronchial inflammation marker |
| Severity of symptoms | Inclusion | — |
| Costs of different types of asthma | Inclusion and after 1 year | Direct and induced costs |
| Control of asthma symptoms evaluated with Asthma Control test and peak exploratory flow | Inclusion | — |
Countries
France
Contacts
Primary ContactChristophe Paris
Outcome results
None listed