Variations in Retinal Nerve Fiber Layer Thickness During Uncomplicated Anterior and Intermediate Uveitis

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02879084

Enrollment

Registered

2016-08-25

Start date

2016-08-31

Completion date

2020-12-31

Last updated

2021-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anterior Uveitis, Intermediate Uveitis

Brief summary

This study investigates the variations in the retinal nerve fiber layer (RNFL) thickness during uncomplicated anterior and intermediate uveitis, respectively. The objectives are to 1 ) confirm the RNFL thickening during an uncomplicated anterior uveitis as described in the literature, 2) measure the RNFL thickness during an uncomplicated intermediate uveitis specifically and 3) describe the variation in time of RNFL thickness during the two types of uveitis.

Detailed description

Thirty six individuals (18 with anterior uveitis and 18 with intermediate uveitis) will be recruited at the Centre universitaire d'ophtalmologie du CHU de Québec. RNFL thickness will be measured with optical coherence tomography at 3 times. For anterior uveitis, the RNFL thickness will be measured at presentation, 1 week and 4 to 6 weeks. For intermediate uveitis, the RNFL thickness will be measured at presentation, 4 to 6 weeks and 4 months. The initial thickness will be studied for each type of uveitis and progression over time will be studied also for each type of uveitis.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* 18 years old or more * anterior uncomplicated uveitis or intermediate uncomplicated uveitis

Exclusion criteria

* history of uveitis in the past, other than the actual uveitis * history of ophthalmologic pathology with potential impact on retinal nerve fiber layer thickness * optic nerve or macular clinically apparent edema * history of glaucoma or other optic neuropathy * suspected or confirmed multiple sclerosis * ocular hypertension (intraocular pressure more than 22 mmHg) * reduced optical coherence tomography signal (lower than 7) on the Cirrus HD-OCT

Design outcomes

Primary

Measure	Time frame
Retinal Nerve Fiber Layer Thickness in anterior uveitis	At time 0
Retinal Nerve Fiber Layer Thickness in intermediate uveitis	At time 0
Change from Baseline Retinal Nerve Fiber Layer Thickness in anterior uveitis	at 4 to 6 weeks
Change from Baseline Retinal Nerve Fiber Layer Thickness in intermediate uveitis	at 4 months

Countries

Canada

Outcome results