Elbow Fracture, Joint Contracture
Conditions
Brief summary
The objective of this study is to obtain and compare bilateral elbow joint synovial fluid from patients with unilateral intraarticular elbow fracture and a contralateral healthy appearing elbow joint. The synovial fluid samples will undergo several forms of analysis for metabolites and proteins. Matched-pair statistical analysis will be performed to determine the metabolites and proteins that may play the greatest role in development of joint contracture.
Interventions
Synovial fluid aspiration (act of using an 18 gauge needle to obtain synovial fluid from the elbow) in the emergency room for patients with the eligible elbow fracture (as defined in inclusion/exclusion criteria) is performed in conjunction with the anesthetic injection as part of standard of care. The elbow will be prepped as per usual for the anesthetic injection. An 18 gauge needle will be inserted through a lateral approach. The subject's elbow will be aspirated. The syringe with the aspirate would be removed from the needle while the needle would remain in the subject's elbow joint. The syringe with anesthetic would then be connected to the needle, and the anesthetic would be injected into the elbow joint. Therefore, no risks from a separate aspiration would be conferred to the patient.
Sponsors
Study design
Eligibility
Inclusion criteria
* 18 years and older * Intraarticular elbow fracture (humerus, radial head and/or ulna fracture)
Exclusion criteria
* Age \<18 years * Open elbow fracture * Bilateral elbow fractures * Patients with history of osteomyelitis of elbow * Inflammatory arthropathy (ie. Rheumatoid arthritis) * Prior surgery on fractured elbow
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| metabolite composition of synovial fluid | time of fracture until surgical fixation (up to 5 weeks after injury) |
Countries
United States