Skip to content

Synovial Fluid Analysis of Intraarticular Elbow Fracture

Synovial Fluid Analysis of Intraarticular Elbow Fracture

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT02878941
Enrollment
12
Registered
2016-08-25
Start date
2017-05-01
Completion date
2020-05-17
Last updated
2020-07-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Elbow Fracture, Joint Contracture

Brief summary

The objective of this study is to obtain and compare bilateral elbow joint synovial fluid from patients with unilateral intraarticular elbow fracture and a contralateral healthy appearing elbow joint. The synovial fluid samples will undergo several forms of analysis for metabolites and proteins. Matched-pair statistical analysis will be performed to determine the metabolites and proteins that may play the greatest role in development of joint contracture.

Interventions

Synovial fluid aspiration (act of using an 18 gauge needle to obtain synovial fluid from the elbow) in the emergency room for patients with the eligible elbow fracture (as defined in inclusion/exclusion criteria) is performed in conjunction with the anesthetic injection as part of standard of care. The elbow will be prepped as per usual for the anesthetic injection. An 18 gauge needle will be inserted through a lateral approach. The subject's elbow will be aspirated. The syringe with the aspirate would be removed from the needle while the needle would remain in the subject's elbow joint. The syringe with anesthetic would then be connected to the needle, and the anesthetic would be injected into the elbow joint. Therefore, no risks from a separate aspiration would be conferred to the patient.

Sponsors

Duke University
Lead SponsorOTHER

Study design

Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* 18 years and older * Intraarticular elbow fracture (humerus, radial head and/or ulna fracture)

Exclusion criteria

* Age \<18 years * Open elbow fracture * Bilateral elbow fractures * Patients with history of osteomyelitis of elbow * Inflammatory arthropathy (ie. Rheumatoid arthritis) * Prior surgery on fractured elbow

Design outcomes

Primary

MeasureTime frame
metabolite composition of synovial fluidtime of fracture until surgical fixation (up to 5 weeks after injury)

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026