Hemiparesis, Stroke
Conditions
Keywords
Prognosis, Hand function, Rehabilitation, Spasticity, MRI
Brief summary
The overall aim is to identify key determinants for recovery of hand function after stroke by applying newly developed hand function measures together with MRI measurements of the lesioned cerebral structures.
Detailed description
Almost half of surviving stroke patients are left with impaired function of the hand but individual profiles of weakness, spasticity, sensory and bimanual function vary widely. Improved prediction of recovery after stroke has broad implications for clinical decisions on the type, duration and goals of rehabilitation. 100 consecutive patients with 1st ever stroke and upper limb hemi-paresis will be subject to imaging, at 4 weeks and 6 months, and behavioral assessments at 4 weeks, 3 months and 6 months after stroke. The imaging protocol includes anatomical sequences for lesion mapping, diffusion tensor imaging and resting-state functional MRI for structural and functional connectivity analyses, respectively. Clinical hand function measures will be combined with novel validated methods to quantify spasticity,grip force control, sensory and bimanual function. ProHand will provide insights into neural mechanisms related to recovery of hand function after stroke and enable enhanced prediction and development of targeted treatment trials.
Interventions
None listed
Sponsors
Danderyd Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* first ever stroke and clinically diagnosed arm paresis
Exclusion criteria
* incapability to give informed concent and/or understand and comply with instructions, other disorders that may affect hand function (e.g. other neurological conditions, arthritis), cerebellar lesions.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in Fugl-Meyer Assessment for Upper Extremity | From 4 weeks to 3 and six months |
Other
| Measure | Time frame | Description |
|---|---|---|
| Change in NeuroFlexor(C) measures | From 4 weeks to 3 and 6 months | Quantitative measures of the neural and biomechanical components of the force resisting passive movement of ther wrist |
| Change in modulation of gripforce: Visuomotor grip force tracking task | From 4 weeks to 3 and 6 months | — |
| Change in Action Research Arm Test, ARAT | From 4 weeks to 3 and 6 months | — |
| Structural and functional connectivity measures; functional Magnetic Resonance Imaging | From 4 weeks to 6 months | — |
| Change in grip force | From 4 weeks to 3 and 6 months | Dynamometry |
| Change in Assisting Hand Assessment, AHA | From 4 weeks to 3 and 6 months | Measures of the spontaneous use of the more affected hand in specific bimanual activities |
| Change in Box and Block Task, BBT | From 4 weeks to 3 and 6 months | — |
| Change in Strength-Dexterity test | From 4 weeks to 3 and 6 months | Dexterous ability/quantification of precision in finger movements |
Countries
Sweden
Contacts
Primary ContactJeanette AM Plantin, PhD student
Backup ContactPåvel G Lindberg, Ass. Prof.
Outcome results
None listed