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The Effect of Vitamin A With and Without Zinc and Multivitamin Supplementation on Malaria Morbidity in Ghanaian Children

The Effect of Vitamin A With and Without Zinc and Multivitamin Supplementation on Malaria Morbidity in Ghanaian Children

Status
Completed
Phases
Phase 3
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT02878265
Enrollment
547
Registered
2016-08-25
Start date
2011-11-30
Completion date
2012-12-31
Last updated
2016-08-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Malaria

Keywords

malaria, vitamin A, Zinc, Multivitamin

Brief summary

The aim of this study was to determine the effect of combining vitamin A (VA), zinc (Z) and multivitamins (MV- A, B1, B2, B6, B12, C, D and E) on malaria morbidity

Detailed description

A total of 542 children aged between 6-59 months received either: (i) VA (control) or (ii) VA & Z (VAZ) or (iii) VA, Z & MV (VAZM). VA was delivered as a single dose while MV and Z were delivered daily. Malaria cases were managed by community health workers, who used rapid diagnostic test to confirm infection prior to treatment.

Interventions

DIETARY_SUPPLEMENTVitamin A

Vitamin A supplements

DIETARY_SUPPLEMENTVitamin A and ZInc

Combination of vitamin A and zinc supplements

DIETARY_SUPPLEMENTVitamin A , Zinc and Multivitamin

Combination of vitamin A, zinc and multivitamins

Sponsors

Kwame Nkrumah University of Science and Technology
CollaboratorOTHER
University of Ghana
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE

Eligibility

Sex/Gender
FEMALE
Healthy volunteers
No

Inclusion criteria

* under 5years * will stay in the community for 10years

Exclusion criteria

* chronic diseases

Design outcomes

Primary

MeasureTime frameDescription
Incidence of clinical malaria attacksBaseline and every month up to six monthsWhile taking the supplement, malaria incidence will be measured

Secondary

MeasureTime frameDescription
Incidence of diarrhea attacksEvery month up to six monthsWhile taking the supplement, diarrhea incidence will be measured

Countries

Ghana

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026