Atrial Fibrillation, Coronary Artery Disease, Elective Coronary Artery Bypass Grafting (CABG) Surgery, Sleep-disordered Breathing (SDB)
Conditions
Brief summary
In patients undergoing elective coronary artery bypass grafting (CABG) surgery, coronary artery disease, sleep-disordered breathing (SDB), atrial fibrillation (AF) perioperative atrial fibrillation and complications will be assessed. The primary objective is to determine, whether SDB patients have a higher rate of Major Adverse Cardiac and Cerebrovascular Events (MACCE) within 30 days after surgery compared to those without SDB.
Interventions
OTHERStratification, no intervention
Sponsors
Michael Arzt
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Patients undergoing elective CABG surgery at the Department of Cardiac and Thoracic Surgery, University Hospital Regensburg. * Written informed consent
Exclusion criteria
* Preoperative use of inotropes or intra aortic balloon pump * Severe obstructive pulmonary disease * Patients on oxygen therapy, nocturnal positive airway pressure support or mechanical ventilation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Major Adverse Cardiac and Cerebrovascular Events (MACCE) | 30 days | periprocedural and late myocardial infarction (MI), non-fatal stroke and transitory ischemic attack (TIA) as well as all-cause mortality |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| MACCE | within 1 and 2 years after CABG surgery | assessed by questionnaire |
| Major pulmonary complications | within 30 days as well as 1 and 2 years | assessed by questionnaire |
| Stroke | within 1 year after CABG surgery | assessed by questionnaire |
| postoperative atrial fibrillation (POAF) | 30 days after CABG surgery | assessed by ECG |
Other
| Measure | Time frame | Description |
|---|---|---|
| postoperative enzymatic myocardial injury | 30 days after CABG surgery | (medical records) |
| postoperative acute kidney injury | 30 days after CABG surgery | (medical records) |
| postoperative delirium | 30 days after CABG surgery | (Questionnaire) |
| general quality of life | 30 days after CABG surgery | (EuroQol - Questionnaire) |
| disease specific quality of life | 30 days after CABG surgery | (Atrial Fibrillation Effect on Quality of Life - Questionnaire) |
| peri- and postoperative respiratory complications (difficult intubation, hypoxemia, respiratory failure, use of extracorporal mechanical oxygenation device) | 30 days after CABG surgery | Assessed from standardized routine clinical records |
| peri- and postoperative hemodynamic instability and heart failure | 30 days after CABG surgery | (medical records) |
Countries
Germany
Contacts
Primary ContactMichael Arzt, MD
Backup ContactStefan Wagner, MD
Outcome results
None listed