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Melatonin Supplementation and Performance

Nocturnal Melatonin Ingestion Ameliorates Short Term Maximal Performances on the Following Day

Status
Terminated
Phases
Early Phase 1
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT02876770
Acronym
MSP
Enrollment
12
Registered
2016-08-24
Start date
2012-12-31
Completion date
2013-01-31
Last updated
2016-08-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Motor Activity

Brief summary

The present study aimed to evaluate the possible effect of nocturnal melatonin ingestion upon short-term performances, on the following morning. Twelve soccer players from a Tunisian squad (22.9 ±1.3 years, 1.80±0.05 m, and 72.0±8.8 kg) were volunteered to perform three testing sessions, with one test session per day. During each session, MEL (5mg) , MEL (8mg) or placebo were ingested, in a randomized order, before nocturnal sleep. The next morning (08:00h), participants performed the following psycho-cognitive and physical tests: Hooper's index, reaction time, vigilance, handgrip strength , squat jump , modified agility test , Wingate anaerobic test (peak power , mean power and fatigue index ). Rating of perceived exertion was recorded immediately after the WanT, and blood lactate measures were taken after 3min of recovery. Blood glucose was measured before and 3 min after the Wingate test.

Interventions

DIETARY_SUPPLEMENTExperimental: Melatonin

Our protocol was composed of three experimental sessions. During each testing session, participants were requested to attend the laboratory at 20:00h where they ingested a standardized light meal. Melatonin (5 mg or 8 mg) or placebo were ingested in capsule in the evening at 21:00h in a double-blind randomized design

DIETARY_SUPPLEMENTPlacebo

In a double-blind randomized design, participants have taken placebo supplementation in one of the three experimental sessions

Sponsors

kais
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE

Eligibility

Sex/Gender
MALE
Age
20 Years to 23 Years
Healthy volunteers
Yes

Inclusion criteria

The participants were recruited based on the following criteria: (i) paticipants must be trained at 4-6 days per week for an average of 2 h daily and (ii) they must have at least 8 years of training experience

Exclusion criteria

* Subjects were excluded from the study if they present one of the following criteria : heart failure, antioxidant supplementation within 3 months before the study, lower-limb injuries

Design outcomes

Primary

MeasureTime frameDescription
Hooper's index scoreAt 07:30 am in the following day of the supplementationHooper's index score was measured using a specific questionnaire
handgrip strength (in Kg)At 07:30 am in the following day of the supplementationhandgrip strength was measured using a calibrated hand dynamometer.
Blood lactate (µmol/l)Blood lactate was measured only 3 minutes after physical testing in the following day of the supplementationLactate level was measured using Lactate Pro instrument.
reaction time (in secondes)At 07:30 am in the following day of the supplementationReaction time was measured using an electronic timing device.
vigilance scoreAt 07:30 am in the following day of the supplementationVigilance score was measured using a specific questionnaire
squat jump (in centimeters)At 07:30 am in the following day of the supplementationSquat jump was assessed using a infrared jump system
agility (in secondes)At 07:30 am in the following day of the supplementationAgility was assessed using an electronic timing system.
anaerobic capacity (In watts)At 07:30 am in the following day of the supplementationAnaerobic capacity was assessed using a calibrated friction-loaded cycle ergometer
glucose level (µmol/l)At 07:30 am in the following day of the supplementation (rest condition) and 3 minutes after physical testing in each experimental sessionGlucose level was assessed using a glucometer
Rating of perceived exertion scoreRating of perceived exertion score was measured 3 minutes after physical testing in the following day of the supplementationRating of perceived exertion score was measured using a specific questionnaire

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026