Obstructive Sleep Apnea
Conditions
Keywords
Obstructive sleep apnea, Aging, Telomere length
Brief summary
Obstructive Sleep Apnea Syndrome (OSAS) regardless of any other associated risk factor can lead to accelerated aging. The study of aging-related Obstructive Sleep Apnea (OSA) is difficult because of associated risk factors (diabetes, hypertension, dyslipidemia, obesity), promoting themselves aging. The investigators propose to compare a group of OSAS patients free of any associated pathology, to subjects matched for age, sex, smoking and body mass index (BMI)
Interventions
OTHERPolysomnography , blood collection, bone densitometry and Functional respiratory explorations
Blood collection, Bone densitometry and Functional respiratory explorations are a specific interventions of protocol for the 3 arms. Polysomnography is a specific intervention for the arms healthy volunteers
Sponsors
Assistance Publique - Hôpitaux de Paris
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
20 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
Patient: * Men aged 20 to 65 years * Having polysomnography in the Functional Explorations department, Sleep Laboratory, Hospital Henri Mondor, Creteil * With an AHI \> 5 / h Healthy volunteers: * Men aged 20 to 65 years * With an AHI ≤ 5 / h
Exclusion criteria
All subjects: * Known cardiovascular risk: hypertension treated, diabetes treated, dyslipidemia treated, * Known cardiovascular disease associated (heart failure, rhythm disorder ...) * Known respiratory diseases * Known neoplastic pathology, known chronic inflammatory disease * Psychiatric pathology treated * Medication * Not affiliated to the French social health care system * Major protected person * Private person of liberty * People in emergency situation * Patient refusing to participate in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Telomere length of circulating leukocytes | 4 weeks |
Secondary
| Measure | Time frame |
|---|---|
| Bone density | 4 weeks |
| Correlation between biological parameters and neuropsychological assessment | 4 weeks |
| Carotid-femoral pulse wave velocity | 4 weeks |
| Markers of inflammation: hs-CRP, IL-6, IL-8, MCP-1 | 4 weeks |
| Markers of growth hormone axis (GH, IGF-1, IGFBP) | 4 weeks |
| Markers of oxidative stress: Malondialdehyde, heme oxygenase-1 | 4 weeks |
Countries
France
Outcome results
None listed