Cataract, Fuchs' Endothelial Dystrophy, Keratoconus
Conditions
Keywords
Corneal Transplantation, Graft Survival
Brief summary
The follow up time after keratoplasty now routinely exceeds multiple decades. It is common for keratoplasty patients to also undergo cataract surgery at a later date in their lives. Keratoplasties and cataract surgery both result in local inflammation. This may influence the density of endothelial cells, and on average there is a loss of 10% in endothelial cells within 3 months of the cataract surgery. Yet, a sufficient density of endothelial cells is required to maintain graft transparency. It may be therefore difficult to strike a balance between loss of visual acuity due to the cataract of to the loss of graft transparency over the long term. The investigators aim to compare graft survival in patients with clear crystalline lens with and without cataract surgery.
Interventions
PROCEDURECataract surgery
Sponsors
Centre Hospitalier Universitaire de Besancon
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
40 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* All patients undergoing keratoplasty * Between january 1983 and december 2012 * Age 40 and older at the time of surgery
Exclusion criteria
* Cataract surgery prior to the keratoplasty * Systemic inflammatory disease * Previous history of uveitis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Corneal transplant graft survival | 10 years |
Secondary
| Measure | Time frame |
|---|---|
| Corneal endothelial cell density | 10 years |
Countries
France
Outcome results
None listed