Sarcopenia
Conditions
Keywords
prevalence; lifestyle modification; clinical outcomes
Brief summary
The purposes of this study were to investigate the prevalence and risk factors for sarcopenia in Chinese adults and elderly, and evaluate the effect of Lifestyle Modification Project (LMP) on Clinical Outcomes, Quality of Life and Cost-effectiveness Ratio.
Interventions
BEHAVIORALnutritional intervention
The intervention is made up of nutrition supplements and dietary pattern modification, which includes whey 30g/d(plus three times every week),vitamin D 1000IU, omega-3 fatty acid (DHA1200mg and EPA 800mg)
BEHAVIORALresistance training program
The training program involve warm-up exercise, muscle strength training and relaxing
BEHAVIORALlifestyle modification project
Lifestyle modification project is made up of multi-dimensional intensive nutritional intervention and resistance training
BEHAVIORALcontrol
The intervention involve dietary pattern modification and protein intake standardization
Sponsors
Peking Union Medical College Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* age\>=18 year The participants must have basic cognitive function and communication Must be able to provide a written informed consent
Exclusion criteria
* age\<18 year Concurrent severe cardiac disease, unstable diabetes mellitus,uncontrolled chronic disease,liver and renal failer, which may significantly interfere with study compliance. Participants received any drugs or supplements known to influence effcet size,such as protein powder, calcium, or vitamin D before the 3 months preceding the study. Participants with electronic or mental device
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| relative skeletal muscle index | 3 months | RSMI(Unit: kg/m2)is defined as muscle mass |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| gait speed | 3 months | GP(Unit: s)is defined as physical activity level |
| quality of life on EQ-5D scale | 3 months | Scores range from 0 \[worse\] to 1\[best\](Unit on a scale) |
| The rate of fracture | 3 months | rate of participants with fracture due to fall(Unit: %) |
| Hand grip | 3 months | HG(Unit: kg)is defined as muscle strength |
| the rate of infection complication | 3 months | Rate of participants with infection complication due to sarcopenia(Unit: %) |
| mortality rate | 3 months | Rate of participants mortality(Unit: %) |
| medical cost on cost-effectiveness ratio | 3 months | the lower cost，the higher effectiveness(Unit: %) |
| the change of physical function on frail index | 3 months | Scores range from 0 \[normal\] to 1\[unhealth\](Unit on a scale) |
Countries
China
Contacts
Primary ContactKang Yu
Outcome results
None listed