Alcohol Abuse, Liver Disease
Conditions
Brief summary
The investigators will test the validity of biomarkers for the detection of heavy alcohol use in patients with and without liver disease.
Detailed description
The investigators will test the validity of biomarkers for the detection of heavy alcohol use in patients with and without liver disease. The investigators will test the validity of carbohydrate deficient transferrin (CDT)(using capillary zone electrophoresis) in blood and ethyl glucuronide (EtG)(using Liquid Chromatography-MS-MS) in hair in patients with heavy alcohol use, moderate alcohol use and patients who do not drink alcohol.
Interventions
PROCEDUREPlasma and head hair collection
Plasma and head hair collection
Sponsors
Universitaire Ziekenhuizen KU Leuven
Study design
Allocation
NON_RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
DIAGNOSTIC
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* patients who do not drink alcohol, moderate drinkers (between 0 and 60 g a day) and patients who drink 60 or more grams alcohol a day
Exclusion criteria
* refusal for inclusion
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| level of disialotransferrin in blood (expressed as percentage di-sialotransferrin) and ethyl glucuronide (expressed in pg/mg) in hair | single determination at inclusion (both on the same day, when patient is seen at the outpatient clinic or when admitted to the hospital) without follow-up | Blood and hair will be collected at one single time-point (procedure of blood and hair sampling takes 30 min) to measure serum CDT and hair ethylglucuronide levels (markers of alcohol use in the prior time period) when the patient presents itself at the hospital, without further follow-up. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| influence of the stage of liver and renal impairment on serum CDT and hair EtG | on the basis of a single determination which is done for the standard care (when patient is seen at the outpatient clinic or when admitted to the hospital) | Blood and hair will be collected at one single time-point (procedure of blood and hair sampling takes 30 min) to measure serum CDT and hair ethylglucuronide levels (markers of alcohol use in the prior time period) when the patient presents itself at the hospital, without further follow-up. Liver and kidney parameters are analyzed in the blood in the context of standard care. |
Countries
Belgium
Outcome results
None listed