Fatty Liver, Steatosis of Liver
Conditions
Keywords
transplantation, liver
Brief summary
A pilot prospective cohort study assessing the clinical utility of MRI evaluation of graft steatosis prior to transplantation will be conducted. An MRI of the donor liver within the transport cooler will be obtained on its way to the operating room.
Detailed description
The images from MRI will be analyzed to obtain information of fat content in all eight segments of the liver. Demographic, intra-operative, and post-operative patient data will be collected for each imaged graft.
Interventions
OTHERMRI of donor liver prior to transplant
MRI of the on ice donor liver within the transport cooler on its way to the operating room
Sponsors
Vanderbilt University Medical Center
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
19 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients who are scheduled to orthoptic liver transplant
Exclusion criteria
* Patient's who do not agree to sign consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Percent Hepatic Steatosis of a Donor Liver Prior to Transplantation | Measured immediately prior to liver transplant | Amount of fat measured in the donor liver prior to transplant surgery using MRI scan |
Secondary
| Measure | Time frame |
|---|---|
| Comparison of steatosis percentages provided by biopsy to MRI results | Baseline |
| Length of hospitalization of transplant recipient | Days to hospital discharge, approximately 2 weeks |
| Mortality of liver transplant recipient at 1 year post transplantation | 1 year |
Outcome results
None listed