Gestational Diabetes and Offspring's Cardiovascular Health: MySweetHeart Cohort

Conditions

Cardiovascular Diseases, Gestational Diabetes Mellitus

Keywords

Cardiovascular diseases, Gestational diabetes mellitus, Pediatrics, Fetal programming, Cohort study

Brief summary

MySweetHeart Cohort is an observational study to assess the effect of gestational diabetes mellitus (GDM) on early life offspring's cardiovascular health. The primary objective is to assess the effect of GDM on the surrogate markers of cardiovascular disease (CVD) at birth (left ventricular mass index and subclinical atherosclerosis). The secondary objective is to assess the effect of GDM on the cardiovascular structure and function during the fetal period and neonatal adverse cardiovascular risk factors. The main hypothesis is that offspring of women with GDM have a larger LVMI and a larger cIMT at birth (primary outcomes) compared with offspring of women without GDM. Further, other hypotheses are that offspring of women with GDM have more foetal cardiovascular alterations and adverse neonatal cardio-metabolic risk factors (secondary outcomes) compared with offspring of women without GDM. My SweetHeart Cohort is linked to MySweetHeart Trial, a randomized controlled trial assessing the effect of a multidimensional interdisciplinary lifestyle and psychosocial intervention to improve the cardio-metabolic and mental health of women with GDM and their offspring. The principal investigators of this trial are Prof Jardena Puder and Dr Antje Horsch from Lausanne University Hospital.

Stefano C. Di Bernardo, Sebastiano A. G. Lava, Adina Mihaela Epure, Sandrine Estoppey Younes, Arnaud Chioléro et al. (23 authors)

Pediatric Research2022-11-2816 citations

10.1038/s41390-022-02390-4

Intuitive Eating Behavior, Diet Quality and Metabolic Health in the Postpartum in Women with Gestational Diabetes

Dan Yedu Quansah, Sybille Schenk, Leah Gilbert, Amar Arhab, Justine Gross et al. (10 authors)

Nutrients2022-10-1312 citations

10.3390/nu14204272

Gestational diabetes mellitus and offspring’s carotid intima–media thickness at birth: MySweetHeart Cohort study

Adina Mihaela Epure, Stefano Di Bernardo, Yvan Mivelaz, Sandrine Estoppey Younes, Arnaud Chioléro et al. (6 authors)

BMJ Open2022-07-015 citations

10.1136/bmjopen-2022-061649

Improving cardiometabolic and mental health in women with gestational diabetes mellitus and their offspring: study protocol for <i>MySweetHeart Trial</i> , a randomised controlled trial

Antje Horsch, Leah Gilbert, Stefano Lanzi, Justine Gross, Bengt Kayser et al. (12 authors)

BMJ Open2018-02-0134 citations

10.1136/bmjopen-2017-020462

Assessing the consequences of gestational diabetes mellitus on offspring’s cardiovascular health: MySweetHeart Cohort study protocol, Switzerland

Stefano Di Bernardo, Yvan Mivelaz, Adina Mihaela Epure, Yvan Vial, Umberto Siméoni et al. (9 authors)

BMJ Open2017-11-0126 citations

10.1136/bmjopen-2017-016972

Interventions

OTHERGDM

Exposure to GDM during fetal life

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Yes

Inclusion criteria

Women aged 18 yrs or older, with or without GDM at 24-32 weeks of gestation, and understanding French or English.

Exclusion criteria

Women on strict bed-rest, with pre-existing diabetes or known severe mental disorder

Design outcomes

Primary

Measure	Time frame
Left ventricular mass index	At birth
Carotid intima-media thickness	At birth

Secondary

Measure	Time frame
Fetal cardiovascular alterations	30-34 wks of gestation (During fetal life)
Fetal left ventricular mass index	30-34 wks of gestation (During fetal life)
Fetal liver volume	30-34 wks of gestation (During fetal life)
Cardiovascular risk factors	At birth

Countries

Switzerland

Outcome results

None listed