Attenuation Artifact, Myocardial Tomoscintigraphy, Patient Position
Conditions
Brief summary
The purpose is to compare percentages of myocardial segments showing attenuation in patients in forward tilted position (biker position) or 2 conventional positions (dorsal decubitus or semi sitting) at acquisition with D-SPECT camera in myocardial tomoscintigraphy. The hypothesis is that the percentage of myocardial segments with attenuation is significantly lower when acquisitions are made in forward tilted position (biker position). The secondary purpose is to restrict this analysis to 3 cardiac regions most subject to attenuation artifacts (anterior, apical and inferobasal regions).
Detailed description
Myocardial perfusion tomoscintigraphy is a very used technique for diagnosis and characterization of abnormalities of stress and rest myocardial perfusion (ischemia, infarction). A common problem is attenuation artifacts that are due to tissue interposition attenuating radiation from some cardiac regions. These artifacts originate activity decreasing and thus perfusion abnormalities potentially in all walls of left ventricle, especially the inferior wall in men (attenuation by sub-diaphragmatic organs) and the anterior wall in women (attenuation by mammary glands). These artifacts are observed in rest and stress acquisitions and can lead to a wrong diagnosis of infarction. Attenuation artifacts can be identified with analysis of contraction kinetics with gated-SPECT (normal kinetics and thus discordant with aspect of infarction). With D-SPECT camera some artifacts can be prevented with a 30-35° forward tilted position of acquisition. This position, also called biker position, can take cardiac area away from sub-diaphragmatic structures. It can also reduce the distance between heart and detection surface of camera and limit respiratory movements of thoracic wall. In this study, patients with abnormal results at stress myocardial perfusion tomoscintigraphy will undergo a rest tomoscintigraphy. Acquisition will be done in forward tilted position and in one of 2 other positions: dorsal decubitus or semi sitting.
Interventions
PROCEDURERest tomoscintigraphy in forward tilted
Rest tomoscintigraphy in forward tilted position
PROCEDURERest tomoscintigraphy in semi sitting position
Rest tomoscintigraphy in forward tilted position, followed by a second rest tomoscintigraphy in semi sitting position, after max 30 min
PROCEDURERest tomoscintigraphy in dorsal decubitus position
Rest tomoscintigraphy in forward tilted position, followed by a second rest tomoscintigraphy in semi sitting position, after max 30 min
Sponsors
Central Hospital, Nancy, France
Study design
Allocation
NON_RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Affiliation to social security * Signed informed consent * Previous clinical examination authorizing patient to undergo tomoscintigraphy * Patient with abnormal results of stress tomoscintigraphy and needing a rest tomoscintigraphy * Patient with sinus and regular cardiac rhythm * Patient with stable clinical status (without signs of unstable cardiac or coronary failure, without uncontrolled hypertension under treatment)
Exclusion criteria
* Women of childbearing potential without effective contraception * Evolutive pregnancy * Breastfeeding patient * Contraindication to tomoscintigraphy * Patient with history of hypersensibility to tomography radiotracer STAMICIS® or one of components * Patient in life-and-death emergency * Patient with history of disorders possibly interfering with contractility * Patient with normal results of stress tomoscintigraphy * Person under legal protection or incapable to consent * Person deprived of liberty by judicial or administrative decision
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Percentage of myocardial segments classified with attenuation artifact | day 0 | With infarction aspect but normal contraction kinetics in Gated-SPECT analysis. Left ventricle is divided in 17 segments according to American Heart Association. |
Secondary
| Measure | Time frame |
|---|---|
| Percentage of myocardial segments classified with attenuation artifact in anterior region | day 0 |
| Percentage of myocardial segments classified with attenuation artifact in apical region | day 0 |
| Percentage of myocardial segments classified with attenuation artifact in inferobasal region | day 0 |
Countries
France
Contacts
Primary ContactMathieu PERRIN, Dr
Outcome results
None listed