28-day Mortality, Sepsis
Conditions
Keywords
BNP, NGAL, Sepsis, Mortality
Brief summary
Objective: to clarify the predictive value of brain natriuretic peptide (BNP) in combination with neutrophil gelatinase associated lipocalin (NGAL) for the prognosis of patients with sepsis.
Interventions
OTHERBNP and NGAL
Sponsors
Southeast University, China
Study design
Allocation
NON_RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
SCREENING
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* age ≥18 years and \<85 years; * presence of severe sepsis according to Survival Sepsis Campaign 10; * all patients voluntarily joined this study with informed consents.
Exclusion criteria
* participated in other trials within 30 days before the criteria for this trial were met; * expected to die within 24 hours; * pregnant; * advanced malignancy with life expectancy \<6 months; * history of congestive heart failure; * chronic renal dysfunction (baseline creatinine \>176.8μmol/L); and * relatives were unwilling to agree to the use of full life support.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| patient-ventilator synchrony for 30mins | 30mins after the patients involved |
Secondary
| Measure | Time frame |
|---|---|
| the numbers of days in the ICU between day 1 and day 28 | the numbers of days in the ICU until day 28 |
| Mechanical ventilation duration between day 1 and day 28 | days of mechanical ventilation between day 1 and day 28 |
| 28-day mortality | 28 days after the patients involved |
Outcome results
None listed