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Extending the hCG OPU Interval

Extending the Time Period Between the Injection of Chorionic Gonadotropin and Oocyte Pick-up as a Solution to Low Rate of Mature Oocyte and Poor Results in Assisted Reproduction

Status
UNKNOWN
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT02871154
Acronym
DelOPU
Enrollment
20
Registered
2016-08-18
Start date
2017-01-31
Completion date
2018-12-31
Last updated
2016-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility

Brief summary

Our and others experience suggest that in some cases delaying oocyte pick up (OPU) for more than 39 hours after hCG injection may be of benefit. We plan to apply this to 20 women in whom less than 20% of oocytes were found suitable for intracytoplasmic sperm injection. The delay will be for up to an interval of 47 hours from hCG to OPU.

Detailed description

In IVF one encounters some women in whom a low percentage of oocytes are found in the metaphase II stage upon their retrieval. Following some incidents, in our experience as well as others', where women injected hCG too early but oocytes were still retrieved with high proportion of maturity, we decided to delay OPU intentionally in women who had low percentage oocyte maturity in previous cycles.

Interventions

OTHERDelaying oocyte pick up beyond 39 hours post hCG

Unlike the traditional less-than 39 hours interval from hCG injection to oocyte pick up, we will extend the interval up to 47 hours

Sponsors

The Baruch Padeh Medical Center, Poriya
Lead SponsorOTHER_GOV

Study design

Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE

Eligibility

Sex/Gender
FEMALE
Age
20 Years to 38 Years
Healthy volunteers
No

Inclusion criteria

Previous 2 oocyte pick up cycles with 20% metaphase II oocytes in the cohort -

Exclusion criteria

No previous IVF history \-

Design outcomes

Primary

MeasureTime frame
ConceptionTwo years

Contacts

Primary ContactIzhar Ben Shlomo, MD
ibenshlomo@poria.health.gov.il972-52-6124781
Backup ContactJohenny S Younis, MD
jyounis@poria.health.gov.il972-50-6265477

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026