Fraction of Inspired Oxygen and Atelectasis in Children

Effects of Fraction of Inspired Oxygen on Atelectasis in Mechanically Ventilated Children

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02870842

Enrollment

Registered

2016-08-17

Start date

2016-09-30

Completion date

2017-01-31

Last updated

2017-08-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pulmonary Atelectasis

Keywords

ultrasonography, child, perioperative period, general anesthesia, lung

Brief summary

Investigators hypothesized that maintaining low fraction of inspired oxygen would be beneficial to prevent anesthesia-induced atelectasis in mechanically ventilated children undergoing general anesthesia.

Interventions

DEVICELung ultrasound

Lung ultrasound on both hemithorax in supine position

OTHERRespiratory management

Appropriate respiratory managements depending on the lung ultrasound findings

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SUPPORTIVE_CARE

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

No minimum to 7 Years

Healthy volunteers

Inclusion criteria

* Expected operation time between 1 to 3 hours under general anesthesia * Mechanically ventilated after endotracheal intubation

Exclusion criteria

* Cardiac, thoracic, abdominal surgery * History of surgery on the lungs * Laparoscopic surgery * Abnormal preoperative chest radiograph findings including atelectasis, pneumothorax, pleural effusion, and pneumonia * Considered inappropriate by the investigator

Design outcomes

Primary

Measure	Time frame
Incidence of postoperative atelectasis	within the first day after the surgery

Secondary

Measure	Time frame
Incidence of atelectasis after endotracheal intubation	from the moment of endotracheal intubation until the end of surgery, up to 4 hours
Intraoperative incidence of pulse oximetry (SpO2) ≤ 95% (or 10% below the baseline value)	from the induction of general anesthesia until the end of the surgery, up to 4 hours
Postoperative incidence of pulse oximetry (SpO2) ≤ 95% (or 10% below the baseline value)	within the first day after the surgery
Postoperative incidence of fever (≥37.5℃)	within the first day after the surgery
Postoperative incidence of respiratory complications	within the first day after the surgery

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026