The Relationship Between Adipokines, Obesity and Insulin Resistance in Women With Polycystic Ovarian Syndrome

Evaluation of Adipokines ( Ghrelin, Resistin and Adiponectin), in Egyptian Women With Polycystic Ovary Syndrome

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02869750

Enrollment

300

Registered

2016-08-17

Start date

2016-11-30

Completion date

2018-09-30

Last updated

2018-10-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Polycystic Ovarian Syndrome

Brief summary

To evaluate possible clinical effects of adipokines , ( ghrelin, resistin and adiponectin), in obese and non-obese patients with polycystic ovary syndrome (PCOS).

Detailed description

Seventy selected PCOS patients will be recruited for this study, and will be divided into two groups based on their body mass index (BMI): 35 obese (BMI≥ 25 kg/m2, group A), 35 non-obese (BMI\<25 kg/m2, group B). In addition, 35 healthy non-obese women (BMI\<25 kg/m2) will bw enrolled as the control (group C). Serum levels of FSH (follicle stimulating hormone), LH (luteinizing hormone), T(testosterone), glucose, insulin, adiponectin, resistin and resistin will bw detected, and compared the differences of them among three groups

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

* Females with PCOS in child bearing age who presented at reproductive and endocrinology clinics at Ain Shams University Maternity Hospital

Exclusion criteria

* Known androgen secreting tumor. * PCO on ovarian stimulation medications * PCO with any other medical illness.

Design outcomes

Primary

Measure	Time frame	Description
serum ghrelin level	24 hours	measuring ghrelin, and ) in the three groups
serum resistin level	24 hours	serum resistin level in the three groups
serum adiponectin level	24 hours	serum adiponectin level in the three groups

Secondary

Measure	Time frame	Description
Glucose/Insulin ratio	24 hours	fasting glucose and insulin in three groups
serum testosterone level	24 hours after labor	serum testosterone level in three groups

Countries

Egypt

Outcome results