Severe Trauma
Conditions
Keywords
Point of Care Device; post traumatic coagulopathy
Brief summary
Traumatic coagulopathy is frequent and is an independent risk factor of mortality. Its detection mainly relies upon classic biological test like the prothrombin time and the international normaliezd ratio (INR). These tests are not available at the bedside. Point of care (POC) device for INR measurement are now available like the Coaguchek, Roche, France. The aim of the present study is to test the correlation between the POC INR and the laboratory INR.
Interventions
DEVICECoagucheck, Roche, France
Capillary puncture for POC INR measurement
Sponsors
University Hospital, Grenoble
Study design
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
15 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age \> 15 y-o * Admission for severe trauma
Exclusion criteria
* Patients under oral anticoagulant
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Concordance between POC INR and laboratory INR using 3 classes: normal < 1.1, moderate : 1.1-1.5, severe: >1.5 | Admission |
Secondary
| Measure | Time frame |
|---|---|
| Prediction of RBC transfusion | 24 hours post admission |
| Prediction of FFP transfusion | 24 hours post admission |
| In-hospital mortality assessed using patients' files | up to Day 28 |
| Injury severity (ISS) | Day 1 |
| Organ failure measured with the SOFA score at Day 1 | Day 1 |
Outcome results
None listed