Correlation Between PET and Advanced MRI in Multiple Sclerosis

Pilot Study of Positron Emission Tomography (PET) Imaging: Correlations With Advanced Magnetic Resonance Imaging in Multiple Sclerosis

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02869360

Enrollment

Registered

2016-08-16

Start date

2016-10-31

Completion date

2019-10-02

Last updated

2019-10-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Multiple Sclerosis

Brief summary

Traditional Magnetic Resonance Imaging (MRI) in Multiple Sclerosis (MS) has enabled clinicians to measure disease activity but there are inherent limitations. Clinical/radiographic dissociation can be seen in some patients and the abnormalities are not specific. This pilot study is an opportunity to determine the relationship between quantitative advanced MRI measures and OCT with PET measurements of microglial activation and myelin health.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

* Diagnosed with Multiple Sclerosis according to the 2011 McDonald criteria. * Aged 18 to 60 * High or mixed affinity binder to rs6971 TSPO polymorphism

Exclusion criteria

* Pregnant or breastfeeding * Suffering from an unstable medical condition * Have a neurological or ocular disorder other than MS * Any contra-indications to MRI

Design outcomes

Primary

Measure	Time frame
Whole Brain PBR28 binding	Baseline

Secondary

Measure	Time frame
Lesional PiB binding	Baseline
Myelin Water Imaging	Baseline
MR Spectroscopy (Total NAA, NAA/Cr, mI)	Baseline
Optical Coherence Tomography (RNFL thickness)	Baseline

Countries

Canada

Outcome results