Colorectal Cancer
Conditions
Brief summary
Previous studies have shown that colorectal cancer patients' prognosis and overall survival was related with immune cell expression in patients' tissue. However, the circulating immune cell activity changes in patients' blood has few studies. The purpose of this study is to analyze the variation of circulating immune cell activity in colorectal patients' blood which is classed as clinical staging.
Detailed description
The patients were classed as clinical staging 1. Early (stage1+2) and Late(stage3+4) 2. regional lymph node metastasis 3. Distant metastasis 4. TNM stage
Interventions
DEVICEEarly stage
patients who classed as clinical stage 1 and 2
DEVICELate stage
patients who classed as clinical stage 3 and 4
Sponsors
Konkuk University Medical Center
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* patient who was planned to undergo colorectal cancer surgery.
Exclusion criteria
* age \< 20 years old * history of hypersensitivity reaction in propofol or sevoflurane * history of previous cancer * patient with ongoing inflammation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Circulating helper T cell activity | preoperative time | change of expression level of T cell (0\ 100 %) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Cytotoxic T cell and natural killer cell activity | preoperative time | change of expression level Cytotoxic T cell and natural killer cell(0\ 100 %)from 0 to 100) |
Other
| Measure | Time frame | Description |
|---|---|---|
| CD4 and Treg cell activity and change of percentage of CD39 and CD73 | preoperative time | change of expression level of CD4 and Treg cell activity and change of percentage of CD39 and CD73(0\ 100 %) |
Countries
South Korea
Outcome results
None listed