Interest of the Injection of Morphine, in Addition to a Local Anesthetic When Performing a Combined Spinal-epidural for Labor Analgesia

Status

Completed

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02868944

Acronym

MASEA

Enrollment

144

Registered

2016-08-16

Start date

2014-08-31

Completion date

2017-01-18

Last updated

2018-01-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pregnant Women

Brief summary

The addition of morphine to a local anesthetic when performing an epidural analgesia during labor analgesia has improved the efficiency and the action duration of analgesia. One limitation of this technique is the time of installation of the analgesic effect (about 30 minutes) when using the only epidural. Therefore, the technique of sequential combined spinal epidural was introduced. This is to shorten the installation time by direct injection into the cerebrospinal fluid. This allows a good efficiency in less than 10 minutes. It has been shown that low doses of sufentanil (strong opioid) in spinal anesthesia could potentiate the effect of the local anesthetic.

Detailed description

Compare the results of obstetric analgesia by sequential combined spinal epidural with local anesthetic injection associated with morphine and a sequential obstetric analgesia by sequential combined spinal epidural with local anesthetic injection alone

Interventions

DRUGexperimental group : sequential combined spinal epidural with local anesthetic injection (chirocaine) associated with morphine (sufentanil).

DRUGcontrol group : sequential combined spinal epidural with local anesthetic injection (chirocaine) alone.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 40 Years

Healthy volunteers

Inclusion criteria

* pregnant patients * patients who experienced a physiological course of pregnancy * patients for which it was estimated eutrophic fetus without pathology found during ultrasound * patient consenting to participate to the study * patient enrolled in the national healthcare insurance program * patient older than 18 years and younger than 40 years

Exclusion criteria

* twin pregnancy * contraindication to sequential combined spinal epidural

Design outcomes

Primary

Measure	Time frame	Description
Visual analog pain scale	after 5 minutes	Pain evaluated inferior at 3 on 10 using a visual analog pain scale

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026