Catatonia, Schizophrenia
Conditions
Brief summary
The different subtypes of Schizophrenia might have a disordered connectivity as their final common pathways. The investigators will use multimodal structural MRI to assess anatomical connectivity on the one side and its functional consequence on functional connectivity on the other side to assess two phenotypes of psychosis : periodic catatonia and cataphasia in comparison with control subjects. The coherence between structural and functional anomalies will be especially studied.
Interventions
OTHERQuantitative multiparametric and functional MRI
Structural connectivity assessed in the cortex and the white matter using multimodal quantitative parametric imaging (R1, R2, R2\*, DTI, susceptibility, macromolecular proton fraction, cortical thickness, VBM). Functional connectivity assessed using simple BOLD and combined ASL-BOLD sequences during multiple tasks including motor, language and working memory tasks.
Sponsors
University Hospital, Strasbourg, France
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
(controls): * Aged from 18-65 Y * Right handed Additional inclusion criteria for patients: * Schizophrenia according to the DSM5 * Either periodic catatonia or cataphasia according to the WKL classification * Under stable medication regimen (\> 1M)
Exclusion criteria
* Current substance abuse * Contraindication to MRI * Past records susceptible to affect brain integrity * Severe, unstable medical condition * Pregnancy * Patients deprived of their rights
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in structural and functional connectivity according to the phenotype. Correlation between these changes | Subjects will be assessed only once. | Statistical parametric mapping (SPM) will be applied on quantitative maps : rCBF (ml/100g/min), susceptibility (part per billion), R1, R2, R2\* (all expressed in ms-1), fractional anisotropy (fraction), averaged diffusivity (μm²/sec), macromolecular proton fraction (percentage), cortical thickness (mm), VBM (probability of grey and white matter) and contrast maps (BOLD signal correlation with the anterior cingulate ROI). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Changes in rCBF and cognition according to the phenotype. Correlation between the different changes and the symptomatic scales. | Subjects will be assessed only once. | Symptomatic scales : PANSS, SANS, SAPS, Calgary, Bush and Francis catatonia scale, the psychological experimental test operationalized for cataphasia, Clinician-rated dimension of psychosis symptom severity questionnaire assessing handedness, anhedonia, vigilance, QoL, activity, handicap, ruminations, depression and personality. Cognitive tests : grammar tests, semantic priming, implicit memory, CPT, fNART, Mill-Hill (part B) |
Countries
France
Outcome results
None listed