Influenza
Conditions
Keywords
Influenza, health care workers, nosocomial, asymptomatic, France
Brief summary
Although clinical presentation of influenza is often symptomatic, asymptomatic cases also occur. The knowledge of the incidence of asymptomatic influenza among healthcare workers is very important because of the risk of cross-transmission to hospitalized patients. The principal objective of the study is to estimate the incidence of symptomatic and asymptomatic influenza among healthcare workers in short-stay wards. The results of this study will lead to a better understanding of the burden of asymptomatic influenza among healthcare workers and might be used as an argument to increase influenza vaccine coverage among healthcare workers.
Interventions
BIOLOGICALBlood sampling
OTHERNasal swab
Sponsors
Hospices Civils de Lyon
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Volunteer health-care workers * Working in the following wards: short-stay, inpatient (including ICU) and emergency
Exclusion criteria
* Presence of influenza symptoms at enrolment * Programmed absence (maternity leave, vacation, etc.) * Administrative agents
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of influenza cases | 6 months after inclusion | Incidence of asymptomatic and symptomatic influenza per 1000 days at risk among healthcare workers |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Fraction of asymptomatic influenza cases | 6 months after inclusion | Fraction of asymptomatic influenza cases among patients with confirmed influenza infection (seroconversion) |
| Stratified incidence ratios | 6 months after inclusion | The objective is to compare the proportion of asymptomatic influenza among vaccinated and unvaccinated healthcare workers, stratified on the type of influenza virus , gender, age, and other covariates |
| Incidence of influenza-like illness | 6 months after inclusion | The objective is to calculate the incidence of influenza-like illness without virological confirmation |
| proportion of health-care workers with Influenza vaccine coverage | 6 months after inclusion | The objective is to estimate the vaccination coverage against influenza among health care workers |
| Number of sick-leave days per participating ward | 6 months after inclusion | The objective is to estimate the professional impact of influenza in a population of healthcare workers |
Countries
France
Outcome results
None listed