Patient Mechanically Ventilated With APRV Mode
Conditions
Brief summary
Mechanical ventilation can induce pulmonary lesions called ventilator induced lung injury (VILI). High levels of Transpulmonary pressure is one of the most important mechanism of VILI during the use of mechanical ventilation. The use of bilevel pressure ventilator modes like APRV could generate high levels of transpulmonary pressure. The aim of this study is to evaluate the variations of transpulmonary pressure during the use of APRV by clinicians
Interventions
OTHERevaluate the variations of transpulmonary pressure during the use of APRV by clinicians.
Sponsors
Assistance Publique Hopitaux De Marseille
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adult * Patient mechanically ventilated for more than 48 H for acute respiratory failure * Decision to use of the APRV mode by clinicians in charge of the patient
Exclusion criteria
\- Contraindication for the use of a nasogastric tube
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Transpulmonary pressure | 24 hours | Measurement of transpulmonary pressure needs the measurement of oesophageal pressure with a specific nasogastric tube. This measurement is now available in routine in few mechanical ventilators in intensive care units (eg: AVEA Ventilator. Vyasys HealthCare). Transpulmonary pressure is the difference between airway pressure and oesophageal pressure and it is now easy to obtain and monitor at the bedside with these ventilators. It is also possible to record the value furthermore than 24 hours. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Maximal value of transpulmonary pressure | 24 hours | Value of tidal volume \> 8 ml/kg |
Countries
France
Outcome results
None listed