Anterior Segment Imaging With Ultrahigh-resolution OCT in Patients With Glaucoma and PEX - a Pilot Study

Anterior Segment Imaging With Ultrahigh-resolution OCT in Patients With Glaucoma and Pseudoexfoliation Syndrome - a Pilot Study

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02865473

Enrollment

Registered

2016-08-12

Start date

2016-04-20

Completion date

2023-12-31

Last updated

2022-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Glaucoma

Keywords

Schlemm's canal lumen area, PEX

Brief summary

The aim of the present study is to develop a measurement protocol for optimal imaging of the anterior segment of the eye, including anterior chamber angle, Schlemm's canal, filtering bleb and pseudoexfoliation deposits on the lens based on measurements in patients with glaucoma and PEX. In glaucoma the structures of the anterior chamber are important for classification, therapy, progression and prognosis and imaging of the angle between the iris and the cornea is the key for open angle and closed angle glaucoma differential diagnosis. For this purpose, a customized ultrahigh resolution Spectral Domain OCT will be used to validate whether the protocol can also be more widely applied in these patients. Based on the obtained measurement protocol, further studies investigating anatomy and pathophysiology of the anterior segment of the eye as well as surgical outcome in patients with glaucoma and PEX can be planned. The aim of the study is to develop a measurement protocol for OCT imaging and characterization of the anterior chamber in glaucoma patients.

Interventions

DRUGPilocarpine

topical instillation into the study eye

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Men and women aged over 18 years For patients with primary open angle glaucoma: * Diagnosed primary open angle glaucoma * Visual field defects and optic nerve head appearance characteristic for glaucoma * Open anterior chamber angle as evidenced by gonioscopy * No previous glaucoma surgery * No previous cataract surgery For patients with primary angle closure: * Angle closure predisposition as evidenced from goniosocopy * No previous glaucoma surgery For patients with neovascular glaucoma: \- Neovascularization in the anterior chamber angle For patients with pseudoexfolation deposits on the lens: * PEX glaucoma as evidenced from slit lamp examination * Visual field defects and optic nerve head appearance characteristic for glaucoma * Open anterior chamber angle as evidenced by gonioscopy * No previous glaucoma or cataract surgery For glaucoma patients with filtering bleb after trabeculectomy: * Patients with history of trabeculectomy secondary to open angle glaucoma in the previous three months * No cataract surgery For healthy volunteers: * No evidence of ocular disease * No degenerative changes in the retina in funduscopy after mydriasis * Ametropia less than 3 dpt.

Exclusion criteria

* Presence of any abnormalities preventing reliable measurements as judged by the investigator * Pregnancy, planned pregnancy or lactating * Ocular inflammation and ocular disease interfering with the study aims as judged by the investigator

Design outcomes

Primary

Measure	Time frame
3-dimensional imaging of the anterior eye segment	1 day

Countries

Austria

Contacts

Primary ContactGerhard Garhöfer, Assoc. Prof. PD Dr.

gerhard.garhoefer@meduniwien.ac.at0043140400

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026