Necrotizing Scleritis
Conditions
Keywords
Scleromalacia perforans, Necrotizing Scleritis, Perichondrium
Brief summary
Necrotizing scleritis with severe ischemia is refractory to conventional treatment because of avascular necrosis. The investigators assessed the therapeutic efficacy and safety of autologous perichondrium transplantation in patients with severe ischemic necrotizing scleritis, and analyzed the therapeutic effects.
Detailed description
Ischemic necrotizing scleritis patients who showed persistent and progressive scleral melting were included in this study. Perichondrium tissue was harvested from the patient's ear cartilage and transplanted to reconstruct the scleral defect after the necrotic tissue removal.
Interventions
PROCEDUREPerichondrium Autografts
Perichondrium tissue was harvested from the patient's ear cartilage and transplanted to reconstruct the scleral defect.
Sponsors
Ministry of Science and ICT, Republic of Korea
Chung-Ang University Hosptial, Chung-Ang University College of Medicine
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
1. impending perforation or perforation state of sclera; 2. graft melting following previous surgery; 3. bacterial or fungal infection of sclera or graft after previous surgery; 4. discomfort due to protrusion of scleral calcification with ischemic necrosis 5. broad avascular area larger than 10 mm in diameter
Exclusion criteria
1. asymptomatic patients 2. smaller scleral defect less than 10 mm in diameter 3. shallow scleral defect
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Success Rate of Repair of Scleral Defects | Six months after reconstructive surgery | Success Rate of Repair of Scleral Defects |
Secondary
| Measure | Time frame |
|---|---|
| Post-Operative Complications | Six months after reconstructive surgery |
Countries
South Korea
Outcome results
None listed