Intestinal Fatty Acid Binding Protein in Very Low Birth Weight Infants With Meconium Obstruction

The Clinical Utility of Urine Intestinal Fatty Acid Binding Protein in the Management of Very Low Birth Weight Infants With Meconium Obstruction

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02864446

Enrollment

100

Registered

2016-08-12

Start date

2012-10-31

Completion date

2015-09-30

Last updated

2016-08-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Meconium Obstruction of Prematurity

Brief summary

Urinary intestinal fatty acid binding protein (i-FABP), a marker of intestinal mucosal cell damage, has recently been proposed as a clinically useful measure in the early detection of necrotizing enterocolitis (NEC). However, there are no data on urinary i-FABP in meconium obstruction of prematurity (MOP). This study aimed to evaluate urinary i-FABP in MOP patient as a marker for early detection.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

No minimum to 36 Weeks

Healthy volunteers

Inclusion criteria

* preterm infants weighing \<1,250g

Exclusion criteria

* major congenital anomalies * perinatal asphyxia (cord pH \<7.0)

Design outcomes

Primary

Measure	Time frame
Comparison of i-FABP level between the meconium obstruction group and the normal feeding advance group	within 48 hours after birth

Other

Measure	Time frame
Comparison of i-FABP level between breast milk feeding and formular feeding in the normal feeding advance group	through study completion (an average of 1 month)
Comparison of i-FABP level between preterm infants with small for gestational age and without small for gestational age in the normal feeding advance group	within 48 hours after birth
Comparision of i-FABP level between preterm infants with chorioamnionitis and without chorioamnionitis in the normal feeding advance group	within 48 hours after birth
Comparision of i-FABP level between preterm infants with maternal pregnancy induced hypertension (PIH) and without maternal PIH in the normal feeding advance group	within 48 hours after birth
Comparison of i-FABP level between preterm infants with maternal premature rupture of membrane (PROM) and without PROM in the normal feeding advance group	within 48 hours after birth

Countries

South Korea

Outcome results