Coronary Artery Disease
Conditions
Brief summary
The aim of this study is to test for an early post-stress cardiac output (CO) change by impedance cardiography and its relation to the severity and extent of myocardial ischemia and angiographic coronary disease in subjects undergoing exercise stress testing using a novel cadmium-zinc-telluride (CZT) SPECT camera.
Detailed description
Single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) is a well-established noninvasive procedure for the evaluation and risk stratification of patients with coronary artery disease (CAD) (1). However, it has been recognized that in certain patients SPECT MPI is unable to detect the presence of or underestimates the extent of CAD. The fact that moderate to severe perfusion defects are noted in less than half of the patients with significant left main disease (2) has stimulated studies to improve the diagnostic accuracy of SPECT MPI. Such studies have analyzed post-stress parameters such as left ventricular (LV) ejection fraction (EF) (3, 4), wall motion abnormalities (5) and transient LV dilation (6) with images acquired on conventional Anger cameras as long as 60 minutes after the stress tracer injection. Such delayed assessment may miss early ischemic stunning as a result of its transient nature. However, detection of an early post-stress decrease in cardiac output (CO) may serve as a potential marker for the presence of significant or extensive ischemia. The aim of this study is to test for an early post-stress CO change by impedance cardiography and its relation to the severity and extent of myocardial ischemia and angiographic coronary disease in subjects undergoing exercise stress testing using a novel cadmium-zinc-telluride (CZT) SPECT camera.
Interventions
a novel cadmium-zinc-telluride (CZT) SPECT camera
OTHERexercise
Sponsors
Sheba Medical Center
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
19 Years to 79 Years
Healthy volunteers
No
Inclusion criteria
* Patients referred to the Nuclear Cardiology Center for a clinically indicated exercise stress MPI study
Exclusion criteria
* known standard contraindications for ergometry * anemia * hyperthyroidism * intra- and extra-cardiac shunts * significant arrhythmia * hemodialysis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Ischemia | 15-20 minutes after stress test | Inducible and reversible perfusion defects, representing myocardial ischemia |
| Cardiac Output | 15-20 minutes after exercise test | Noninvasive evaluation of cardiac output using a novel algorithm based on impedenace |
Contacts
Primary ContactRonen Goldkorn, MD
Outcome results
None listed