Follow-up of Chronic Hepatitis B Patients With Comorbid Nonalcoholic Fatty Liver Disease

Disease Progression and Clinical Outcomes in Chronic Hepatitis B (CHB) Patients With Comorbid Nonalcoholic Fatty Liver Disease (NAFLD)

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02863757

Enrollment

1500

Registered

2016-08-11

Start date

2016-08-01

Completion date

2026-12-01

Last updated

2026-07-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Hepatitis B, Nonalcoholic Fatty Liver Disease

Brief summary

The purpose of this study is to determine the disease progression in CHB/NAFLD compared with CHB and NAFLD including liver cirrhosis, cirrhotic complications and hepatocellular carcinoma (HCC).

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* Liver biopsy proved CHB and/or NAFLD at baseline; * Chinese * Follow-up duration\>12 months

Exclusion criteria

* Other liver diseases; * Secondary causes of hepatic steatosis; * Alcohol abuse; * Liver cirrhosis, cirrhosis related complications or HCC at baseline; * Malignancy; * History of liver transplantation

Design outcomes

Primary

Measure	Time frame
Number of patients with liver cirrhosis, hepatic encephalopathy, esophageal varices, ascites and hepatocellular carcinoma	Up to 20 years

Secondary

Measure	Time frame
Number of patients with hypertension, obesity, diabetes mellitus, hyperlipidaemia	Up to 20 years
Number of patients with liver transplantation and liver-related death	Up to 20 years
Diagnosis time of liver cirrhosis, hepatic encephalopathy, esophageal varices, ascites and hepatocellular carcinoma from baseline	Up to 20 years
Occurrence time of liver transplantation and liver-related death from baseline	Up to 20 years

Countries

China

Contacts

CONTACTGeorge Lau, MD

gkklau@netvigator.com+852 2861 3777

Outcome results