Subfertility, Infertility
Conditions
Brief summary
The aim of this study is to evaluate whether Ibuprofen alone or combined with lorazepam reduce the pain associated with endometrial scratching/injury.
Interventions
Sponsors
University of Sao Paulo
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Women aged ≥ 18 years undergoing assisted reproduction (IUI, IVF/ICSI, frozen embryo transfer) * Being submitted to endometrial scratching/injury with a Pipelle on the first four days of the menstrual cycle. * Not have performed endometrial scratching in the last 90 days.
Exclusion criteria
\- None
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Maximum pain during procedure | 5 minutes | Evaluated by both visual analog scale (10 cm) and numeric verbal scale (0 to 10). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Pain after the procedure | 5 minutes | Evaluated by both visual analog scale (10 cm) and numeric verbal scale (0 to 10). |
| Rejection to a new procedure | 5 minutes | Evaluated by a 5-point Likert scale, commenting on this sentence: I would repeat this procedure if it were indicated. 1 = I fully agree; 2 = I agree; 3 =Neither agree nor disagree; 4 = Disagree; 5 = Strongly Disagree. |
Outcome results
None listed