Colon Cancer, Lymph Node, Sentinel Node
Conditions
Keywords
colon cancer, sentinel node
Brief summary
Unmask Trial aims to evaluate the Kappa concordance between immunochemistry and molecular biology to detecting cancer cells in sentinel lymph node in patients undergoing colectomy for non metastatic colon cancer.
Interventions
PROCEDUREImmunochemistry and molecular biology on sentinel lymph node specimen
Sponsors
Centre Hospitalier Universitaire de Besancon
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Colectomy for Non metastatic colon cancer
Exclusion criteria
* Tumor T4 * No medical insurance * Pregnant woman * Psychiatric disorders
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Concordance between immunochemistry and molecular biology | 1 month | The primary outcome is the rate of concordance between the number of positive sentinel lymph nodes detected by immunochemistry using an anti-cytokeratin antibody (KL1) and molecular biology targeting CK20 on tumoral RNA after RT-PCR. The rate of positivity of the sentinel lymph nodes will be then compared to the standard technique using HES coloration used in routine pathological examination. Only the result using the routine examination will be used to decide whether the patient should benefit from an adjuvant chemotherapy. |
Secondary
| Measure | Time frame |
|---|---|
| Disease-free survival | 3 years |
Countries
France
Outcome results
None listed