Bladder Cancer
Conditions
Brief summary
This research aims to explore the therapeutic effect of neoadjuvant chemotherapy in muscular invasive bladder cancer of T2-4aN0M0, and the survival effect of combined-modality treatment model，then to clarify the probability of bladder preservation, corresponding cancer specific survival, and the quality of life.
Interventions
PROCEDUREIntensity modulated radiation therapy, Radical cystectomy
Postoperative Intensity modulated radiation therapy(IMRT) will be applied to effective team.Radical cystectomy will be applied to ineffective team.
Sponsors
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
1. bladder urothelium carcinoma 2. cT2-4aN0M0 3. life expectancy≥1 year 4. ECOG PS 0-1 5. have no previously received radiotherapy or chemotherapy 6. have no major organ dysfunction 7. have been provided informed written consent
Exclusion criteria
1. extensive carcinoma in situ or ureter invaded 2. distant metastasis at primary diagnosis or lymphatic metastasis according to clinical diagnosis 3. have severe major organ dysfunction 4. cannot finish treatments because of other severe diseases or life expectance≤6 months 5. exist other malignant tumors 6. have severe coagulation disorders 7. no other trails participated in 4 weeks
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| bladder preservation rate | 3 years | bladder preservation rate |
Countries
China
Outcome results
None listed