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Randomized Controlled Trial of Ultrasound-guided Versus Landmark Technique for Peripherally Inserted Central Catheter (PICC) Placement

Status
Completed
Phases
Phase 3
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT02859987
Enrollment
199
Registered
2016-08-09
Start date
2013-08-31
Completion date
Unknown
Last updated
2016-08-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

PICC Placement

Keywords

US, Nursing Services

Brief summary

Peripherally Inserted Central Catheter (PICC) are intravascular devices used on patients undergoing IV therapy. Insertion of these catheters can be achieved either by using the anatomical landmarks for the veins or using ultrasound guidance. The guidelines recommend the use of ultrasound guidance for central venous access catheterization to facilitate central venous cannulation (CVC) and to reduce the risk of complications, but the scientific evidence is limited and heterogeneous. This is a prospective randomized clinical trial in adults patients requiring peripherally inserted central catheter (PICC) placement for intravenous therapy. The principal aim of this randomized clinical trial is to evaluate the effectiveness of ultrasound-guidance technique for successfully peripherally central venous catheterisation in the first attempt versus landmark method, in the context of PICC cannulation. Patients are randomized (1:1) in two groups: Control arm (landmark technique) versus Experimental group (ultrasound guidance technique). In order to avoid expected biases the investigators stratified the cases by difficulty for venous cannulation. Crossover was allowed if catheterisation could not be reached after two unsuccessful venipunctures, to prevent suffering of the patients and troubles in its care.

Interventions

PROCEDUREPICC Placement by Landmark Technique

Comparison of two different techniques for PICC Placement (Landmark versus Ultrasound-guided)

PROCEDUREPICC Placement by Ultrasound-guided Technique

Comparison of two different techniques for PICC Placement (Landmark versus Ultrasound-guided)

DEVICEUltrasound Scan

Initially the nurses use ultrasound for explore venous anatomy and then they use real-time ultrasound imaging during needle placement

Sponsors

Hospital San Carlos, Madrid
CollaboratorOTHER
Equipo de Terapia Intravenosa
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Signed and dated informed consent. * Patients with indication of PICC insertion for long-term intravenous therapy

Exclusion criteria

* Peripheral vascular disease * Injecting drug users

Design outcomes

Primary

MeasureTime frameDescription
Evidence of catheter inserted at first attempt, correctly located (after chest X-ray performed) and proper working, confirmed by the nurseWithin the first 6 hours after placementThe principal aim is to evaluate the effectiveness of ultrasound-guidance technique for successfully peripherally central venous catheterisation in the first attempt versus landmark method, in the context of PICC cannulation

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026