Olfactogustatory Perception, Eating Behaviour and Inflammation in Crohn's Disease

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02859675

Acronym

Smell&Crohn

Enrollment

Registered

2016-08-09

Start date

2013-10-07

Completion date

2021-05-03

Last updated

2024-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Crohn's Disease, Olfactogustatory Perception

Brief summary

This study will improve our understanding of the mechanisms underlying anorexia in persons with Crohn's disease flare-ups. The practical spin-off from this research is potentially very important for the management of nutritional disorders associated with the disease by guiding diets towards foods that correspond to patients' preferences and/or to modified tastes. In addition, the results could lead to the identification of sensory markers that herald an inflammatory flare-up of the disease.

Interventions

OTHERtriangular test

metabolic state, impedance measurement, potential flavours evoked by sucrose,

BIOLOGICALblood sampling

sampling of 2 mL

OTHERQuestionnaires

Stunkard, PrefQuest

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

For patients : Inclusion Criteria: * Age between 18 and 60 years, * Diagnosis of Crohn's disease according to clinical, endoscopic, histological, radiological and biochemical criteria as defined by the European Consensus Conference, * Men or women who have provided consent and willing to cooperate.

Exclusion criteria

* Chronic inflammatory intestinal disease (CIID) other than Crohn's disease: haemorrhagic rectocolitis, undetermined colitis, microscopic colitis. * Intercurrent disease (diabetes and metabolic disease, liver cirrhosis, progressive cancer, acute or chronic infection, Human Immunodeficiency Virus HIV), * Organ failure (respiratory, heart, or renal failure, neurological disorders), * Intolerance to gluten, * Treatments (other than those used for Crohn's disease) able to interfere with food intake, * Aversion to foods consumed or smelled, * Poor understanding of cognitive tasks required. * Crohn's disease complicated by an abscess or infectious complication * Acute Crohn's disease defined by a CDAI score \> 150 For Controls: Inclusion Criteria: * Adult person * Without follow-up for a chronic pathology * Having given its consent

Design outcomes

Primary

Measure	Time frame	Description
Modification of sweet taste	through the study completion up to 10 years	the measurement of detection thresholds consists in presenting to the participants in order of increasing concentrations, series of forced-choice triangular tests

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026