Pronostic Value of Endothelial Dysfunction in Heart Failure

Status

Terminated

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02859636

Acronym

Pro-ICARD

Enrollment

Registered

2016-08-09

Start date

2012-10-31

Completion date

2016-03-31

Last updated

2016-08-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiac Failure, Heart Decompensation

Brief summary

The main objective is to evaluate the pronostic value of endothelial dysfonction in acute heart failure on a combined criteria associating cardiovascular mortality, nex hospitalisation for decompensated heart failure, cardiac graft or ventricular assistance 2 month and 1 year before acute heart failure.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 81 Years

Healthy volunteers

Inclusion criteria

* patients hospitalized for acute heart fialure with Left Ventricular Ejection Fraction (LVEF) \< 45 % on echocardiography

Exclusion criteria

* Informed consent form not signed * Cardiogenic, septic or hemorragic shock * Acute coronary syndrom with elevated troponin * valvular surgery or aorto-coronary graft during next 3 months * Cancer * Pregnancy * life expectancy over than 1 year * chronic renal impairment

Design outcomes

Primary

Measure	Time frame	Description
MR Proadrenomedulline	6 months	—
catecholamins	6 months	—
late endothelial progenitors	6 months	—
Peripheral tissular perfusion	6 months	Near infra-red spectroscopy
mortality	6 months	—
hospitalisation	6 months	—

Outcome results