Eating Behaviour and Gustatory Sensitivity Before and After Liver Transplant in Cirrhotic Patients

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02859506

Acronym

GREFFE

Enrollment

Registered

2016-08-09

Start date

2015-07-03

Completion date

2019-12-13

Last updated

2024-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Eating Behaviour, Liver Transplant

Brief summary

Today, we know that olfactogustatory alterations occur in cirrhotic patients before the liver transplant but no study has been conducted to show eventual disturbances after the transplantation able to explain modifications in eating behaviour. In parallel, the metabolic status, itself dependent on liver metabolism, influences food preferences and is modified after the transplantation as the liver recovers its ability to store glycogen, but is not able to inform the brain as the afferent nerve impulses have been suppressed. The innovative aspect of this project is to provide information on the importance of the liver in the regulation of energy homeostasis. The results of this study will improve our understanding of eating behaviour and olfactogustatory sensitivity and allow us to orient liver transplant patients towards appropriate diets.

Interventions

OTHERRespiratory quotient

OTHEROlfactory liking

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

OTHER

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Healthy volunteers

Inclusion criteria

* persons who have provided written informed consent * persons aged between 18 and 70 years * persons waiting for a liver transplantation (group LT) * persons with stable liver damage * persons waiting for a kidney transplantation (KT) * healthy subjects (control group) no known disease

Exclusion criteria

* persons without national health insurance cover * persons with chronic infection, * persons with acute infection, * persons with progressive cancer, * persons with an antibiotic treatment, * persons who drink alcohol, * pregnant or breast-feeding women, * persons with an aversion to the foods proposed in the study, * persons taking treatments known to interfere with gustatory and olfactory performance, * adults under guardianship

Design outcomes

Primary

Measure	Time frame
Change in respiratory quotient (RQ) by indirect calorimetry compared with baseline values	At month 0, month 3, month 9 and month 15
Change in olfactory liking compared with baseline values by questionnaire	At month 0, month 3, month 9 and month 15

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026