Neonatal Bacterial Infection
Conditions
Keywords
neonatal bacterial infection, procalcitonin
Brief summary
After birth, in the presence of risk factors for early neonatal bacterial infection (IBNP), the pediatrician must make a difficult decision quickly or not to prescribe additional examinations and / or hospitalize or not the newborn in order to administer parenteral antibiotics. This decision takes into account several contextual data, (clinical, biological and bacteriological clinical data) to be considered simultaneously. These information lack sensitivity and specificity. Therefore, the common attitude among newborns in many countries remains the achievement of a significant number of additional tests and the establishment, without a prior evidence of infection, intravenous empirical antibiotic therapy for 48 -72h at least in hospitalization. However, the diagnosis of IBNP posteriori, is often reversed. This attitude is: 1. one source to higher health care costs (hospitalization, additional examinations) 2. Selection of the bacterial ecology of the newborn and neonatal services and 3. stress for the newborn and parents
Interventions
BIOLOGICALdosage of the umbilical cord blood Procalcitonin for diagnosing of IBNP
Sponsors
University Hospital, Montpellier
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
1 Minutes to 30 Minutes
Healthy volunteers
Yes
Inclusion criteria
* Birth to motherhood. * Term \> 34 weeks . * Presence of at least one of the factors of major or minor infection risk
Exclusion criteria
* cord blood sample unavailable. * Death in the delivery room * Corticosteroids prenatally (modification of cytokine production ) .
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| value of the procalcitonin in the umbilical cord blood | up to 1 hour |
Countries
France
Outcome results
None listed