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The Effect of Semi-solid Feeding After Percutaneous Endoscopic Gastrostomy (PEG) on the Incidence of Aspiration Pneumonia and Postoperative Length of Stay

The Effect of Semi-solid Feeding After Percutaneous Endoscopic Gastrostomy (PEG) on Clinical Outcomes, Specifically the Incidence of Aspiration Pneumonia and Postoperative Length of Stay

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT02858596
Enrollment
136
Registered
2016-08-08
Start date
2014-01-31
Completion date
2015-12-31
Last updated
2016-08-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aspiration Pneumonia, Gastrostomy

Brief summary

Percutaneous endoscopic gastrostomy (PEG) is a minimally invasive procedure for long-term enteral tube feeding in patients with insufficient oral intake. Although peristomal site infection is often noted as the most common adverse event after PEG tube placements, it is seldom life-threatening and considered a minor adverse event. Feeding-related adverse events have been identified as the main cause of death after PEG, with up to 50% of postoperative early mortality (30 days) being attributed to aspiration pneumonia. This may be related to the persistence of gastroesophageal reflux (GER) of enteral feed after gastrostomy, even though PEG have been demonstrated to be superior to nasogastric tube feeding in terms of preventing GER. It has been more than a decade since semi-solid feeds were developed as an alternative to conventional liquid feeds to prevent feeding-related adverse events. Unfortunately, there is limited published literature on this topic despite the wide usage of this feeding method in Japan. Amidst the growing popularity of this method and the introduction of National Healthcare Insurance coverage for semi-solid feed prescriptions, we initiated a semi-solid feed protocol along with our existing post-PEG feeding protocols in 2014.

Interventions

DIETARY_SUPPLEMENTSemi-solid feed (Terumo PG soft)
DIETARY_SUPPLEMENTLiquid feed (Meibalance)

Sponsors

Hiroshima Kyoritsu Hospital
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE

Eligibility

Sex/Gender
ALL
Healthy volunteers
No

Inclusion criteria

* Patients receiving gastrostomy tube placement in our hospital for enteral nutrition.

Exclusion criteria

* Patients receiving gastrostomy tube placement for decompression * Patients with no gut usage more than 2 weeks before procedure

Design outcomes

Primary

MeasureTime frame
Incidence of aspiration pneumoniathrough study completion, average 90 days postoperation

Secondary

MeasureTime frame
Postoperative length of staythrough study completion, average 90 days postoperation

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026