Neuropathic Pain
Conditions
Brief summary
Neuropathic pain is a medical condition involving allodynia (painful perceptions in response to stimuli that normally are not) and spontaneous pain (occurring at rest, without stimulation). This pain is secondary to nervous system injury affecting the sensory system. The lesion is either at the nerve endings of the spinal cord or brain. It induces a loss of sensitivity and reorganization of brain activity. Previous studies in functional neuroimaging have focused on brain areas activated during allodynic stimuli compared to non-painful stimuli. The abnormalities have been reported, but it was not possible to conclude formally. The objective of this study is to understand the brain dysfunction that induces allodynic pain considering the deafferentation of each patient and possible cortical losses.
Interventions
OTHERstimulation on painful area (area allodynic)
these stimulations will be performed either with a brush, with a cold block or with forced air (cold air or air to ambient temp) : calibrated to induce pain bearable. stimulations for 6 seconds
OTHERsame stimulation on non-painful area
these stimulations will be performed either with a brush, with a cold block or with forced air (cold air or air to ambient temp) : calibrated to induce pain bearable. stimulations for 6 seconds
RADIATIONMRI scan
2 sessions for 10 minutes : * 11 controls stimulations for 6 s each spaced 20 s without stimulation. * 11 allodynic stimulations for 6 s each spaced 20 s without stimulation.
Sponsors
Centre Hospitalier Universitaire de Saint Etienne
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* with neuropathic pain * in the case of central lesions, the lesion must be unique and small * treatment not stable opioid for one week * consent signed
Exclusion criteria
* severe psychiatric history * presence of an evolutive lesion, expansive, cancerous or tumorous underlying * patient needing of opioid therapy * contraindication at MRI scan
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| the deafferentation rate | at baseline | the deafferentation rate measured with thermo-test |
| gray matter rate | at baseline | gray matter rate measured with MRI scan |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Analysis pain | at baseline | Measured by visual analogue scale (0 to 10) |
Countries
France
Outcome results
None listed