Neuropathic Pain
Conditions
Brief summary
Neuropathic pain is a medical condition involving allodynia (painful perceptions in response to stimuli that normally are not) and spontaneous pain (occurring at rest, without stimulation). This pain is secondary to nervous system injury affecting the sensory system. The lesion is either at the nerve endings of the spinal cord or brain. It induces a loss of sensitivity and likely reorganization of brain activity that are causing pain and which are the subject of this study. Previous studies in functional neuroimaging has focused on brain areas activated during allodynic stimuli compared to non-painful stimuli. The abnormalities have been reported, but it was not possible to conclude formally. The authors failed to assess the part of the effect of the loss of sensory afferents (deafferentation) and the basal brain function. Indeed, the operation without any sensory stimulation is not known yet is the initial level of activity which is the benchmark for studying brain function during stimulation. The objective of this study is to understand what are the cortical systems of allodynic dysfunctional in patients compared with controls at baseline.
Interventions
RADIATIONMRI scan
Sponsors
Centre Hospitalier Universitaire de Saint Etienne
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
for patients : * major * with nervous pain : chronic or peripheric * treatment not stable opioid since one week * signed consent Inclusion Criteria for witnesses : * major * without chronic pain * signed consent
Exclusion criteria
for 2 groups : * severe psychiatric history * presence of an active nervous lesion * subject with morphine treatment * contraindication to MRI scan
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| cerebral blood flow | at baseline | quantified with MRI scan |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| rate of grey matter | at baseline | difference between groups |
| structure of the networks | at baseline | Determine if structure of the networks is different between patients and controls. Measured with MRI scan. |
| connection of the networks | at baseline | Determine if connection of the networks is different between patients and controls. Measured with MRI scan. |
| cortical loss | at baseline | Assess the cortical loss of the patient group compared to controls. Measured with MRI scan. |
Countries
France
Outcome results
None listed