Suicide
Conditions
Keywords
cognitive inhibition, elderly, suicide attempt, depression
Brief summary
The study aims to determine the correlation between the cognitive inhibition impairment and the history of suicide attempt in elderly depressed patients.
Detailed description
2 groups of patients will be studied: in the first group, depressed patients with a history of suicide attempt will be included whereas in the second group, depressed patients without a history of suicide attempt will be included. For each group, the cognitive inhibition will be assessed trough an eye tracker task (antisaccade). Both groups will also be compared on their neuropsychological characteristics and the quality of social interactions of participants.
Interventions
BEHAVIORALeye tracking
several oculomotor parameters will be recorded using vide-oculography techniques (eye tracking) trough different tasks: saccade, antisaccade, and picture scanning. Saccade task: the patient is looking at a screen and is asked to fix his gaze as quickly and accurately as possible on the red dot appearing on the periphery of the screen. Prosaccade task: the patient is looking at a screen and is asked to fix his gaze as quickly and accurately as possible on the opposite side relative to the red dot appearing on the periphery of the screen. Picture Scanning: participant is instructed to freely watch pictures with different emotional valence.
BEHAVIORALneuropsychological assessement
the neuropsychological assessment aims to identify any impairment of executive functioning through several tasks: Mini mental state examination (mmse), isaac set test (STI) trail making test (TMT A and B), Grober test, Stroop test, verbal fluency, Go No Go task, memory impairment screen (MIS), picture naming test (DO30), copying figure test, digit span and categorical matching test.
BEHAVIORALpsychiatric assessment
this evaluation aims to characterize the mental status of the patient. Different scales will be used: Montgomery and ASberg depression rating scale (MADRS), Columbia-suicide severity rating scale (C-SSRS), Beck depression inventory (BDI), Barratt impulsiveness scale (BIS-10), Buss and Durkee Hostility Inventory (BDHI), Balloon, analogue risk task (BART), Iowa gambling task (IGT), and Childhood trauma questionnaire (CTQ).
BEHAVIORALsociological interview
this interview aims to characterize social interactions of the patients, their duration, their evolution and the perception of each participant on this subject.
Sponsors
Centre Hospitalier Universitaire de Besancon
Study design
Allocation
NON_RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
SCREENING
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* major depressive disorder according to Diagnostic ans Statistical Manual (DSM) V * group 1: with a history of suicide attempt * group 2: without a history of suicide attempt
Exclusion criteria
* other psychiatric disease * guardianship
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| antisaccade error rate | 1 month max. after inclusion |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| saccade accuracy | 1 month max. after inclusion | distance between the eye position at the end of the first saccade, and the ideal position to engage the target in central vision |
| saccadic intrusion | 1 month max. after inclusion | gaze deviation into a saccade greater than 3° during visual fixation |
| maximal speed of the gaze | 1 month max. after inclusion | maximum speed of visual tracking without triggering any saccade |
| saccade reaction time | 1 month max. after inclusion | — |
| fixation duration on pictures | 1 month max. after inclusion | — |
| social interaction quality score | 6 month max. after inclusion | — |
Other
| Measure | Time frame |
|---|---|
| neuropsychological test score | 1 month max. after inclusion |
Countries
France
Contacts
Primary Contactjulie monnin, PhD
Backup Contactkristina mouyabi
Outcome results
None listed