Lymphoma
Conditions
Brief summary
The purpose of this study is to define a reference population for FDG-PET neurological examinations starting from patients having FDG-PET to supervise a non-complicated lymphoma (tumor in remission, low disabling chronic tumor).
Detailed description
This study will also check normality of cerebral functions in this population and analyse the influence of various variation factors, such as age, sex ratio, education level, professional activity and neuropsychological test results on normal data. This database could be later used as comparison to patient images defining the gravity and localization of their cerebral functional disorders.
Interventions
DEVICEFDG-PET
FDG injection followed by cerebral examination with X ray spiral CT after 40 minutes and FDG-PET after 60 minutes
Sponsors
Central Hospital, Nancy, France
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
21 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Patient with tumor in remission or low disabling chronic tumor * No parenteral chemotherapy for at least 1 month * No glucocorticoid treatment * No general health modification (asthenia, anorexia, weight reduction)
Exclusion criteria
* Patient having a known neurodegenerative disorder, a general disease or physical problems that can interfere with cognitive function * Patient with cerebral pathology history (epilepsy, vascular event, cerebral vascular malformation, tumor, severe cranial trauma, meningitis or infectious or inflammatory encephalitis, hydrocephalus, mental retardation…) * Patient not having at least 4 years of education * Patient having an anxiolytic or anti-depressive treatment * Patient refusing to participate to the study * Patient incapable to give informed consent (guardianship)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Absence of cerebral abnormalities detected with X ray spiral CT | Day 0 |
| Mini International Neuropsychiatric Interview (DSM-IV) score | Day 0 |
| Montgomery-Åsberg depression rating scale | Day 0 |
| Absence of cerebral abnormalities detected with PET | Day 0 |
| Absence of neurological impairment detected during standard neurological examination | Day 0 |
| Mini-mental state score | Day 0 |
| Frontal Assessment Battery score | Day 0 |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Cerebral FDG distribution | Day 0 | Voxel-based analysis with SPM software of PET data |
| FDG mean activity in cerebral sections | Day 0 | Automatic measurement of FDG mean fixation in cerebral sections with NeurogamTM (Segami) software in PET data |
| Instrumental Activities of Daily Living evaluation | Day 0 | Evaluation of the normality of cerebral function in study population |
Countries
France
Outcome results
None listed